F02110302 | Accumulation of calcium
| Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Diclofenac | 50 μmol/L | 2 minutes | rat | liver mitochondria | Assessment of Mitochondrial Ca2+ Efflux; Energized with succinate | decrease | Positive | not mentioned | 6 |
| CGP37157 | 1 μmol/L | periodically paced rat ventricular myocytes (VMs) under β-adrenergic stimulation | mitochondrial Ca2+ monitored by mitochondrial-targeted Ca2+ biosensor mtRCamp1h. | Positive | 241 | ||||
| kaempferol | 10 μmol/L | periodically paced rat ventricular myocytes (VMs) under β-adrenergic stimulation | mitochondrial Ca2+ monitored by mitochondrial-targeted Ca2+ biosensor mtRCamp1h. | Positive | 241 | ||||
| Troglitazone | 50 μM | male CD-1 mice | isolated liver mitochondria | Assessment of mitochondrial Ca2+ efflux with arsenazo III at 675/685 nm. | decrease | Positive | 331 | ||
| Ciglitazone | 50 μM | male CD-1 mice | isolated liver mitochondria | Assessment of mitochondrial Ca2+ efflux with arsenazo III at 675/685 nm. | decrease | Positive | 331 | ||
| neomycin | 400 μM | zebrafish | zebrafish lateral line hair | measrueing cytoplasmic oxidation (HyPer) and mitochondrial Ca2+ uptake (mitoRGECO) | increase | Positive | 315 | ||