Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Emtricitabine							Positive		194
Zidovudine						increase	Positive		307
Acyclovir						increase	Positive		307
Ganciclovir						increase	Positive		307
Zalcitabine						increase	Positive		307
Abacavir							Positive		185
Ciprofloxacin						decrease	Positive		307
Ciprofloxacin						decrease	Positive		307
Menadione	6.0 μM	1 hours	human	pFastBac	Meassurement of DNA polymerase gamma activity	affect	Positive	IC50	9
Dequalinium Chloride		24 hr		Caco-2 and Ishikawa cells	Relative quantification of mtDNA copy number was measured using the QuantiTect SYBR Green PCR kit	decrease	Positive		299
Cisplatin		24 hr		Caco-2 and Ishikawa cells	Relative quantification of mtDNA copy number was measured using the QuantiTect SYBR Green PCR kit	decrease	Positive		299
Zalcitabine							Positive		194
Didanosine							Positive		194
Stavudine							Positive		194
Lamivudine							Positive		194
Tenofovir							Positive		194
Zidovudine							Positive		194
Carbovir							Positive		194
Abacavir							Positive		194
Fialuridine							Positive		194

F060101. mitochondrial DNA metabolic process
F060102. mitochondrial DNA metabolic process
F060103. mitochondrial DNA metabolic process
F060104. mitochondrial DNA metabolic process
F060105. mitochondrial DNA metabolic process

T234. DNA polymerase gamma