Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
---|---|---|---|---|---|---|---|---|---|
MG-132 | 20 μM | 24 hr | rat | PC12 cells | Measurement of caspase-3 activity with ApoAlert™ CPP32/Caspase-3 assay kit | increase | Positive | 289 | |
Troglitazone | 100 µM | 24hr | HepG2 cells | Apo-One homogeneous caspase 3 assay kit | Positive | 330 | |||