F070105 | Cytochrome c release

GO:0001836
Cell death >> Apoptosis >> cytochrome c release

Compound Dose Time Species Model Method Action Result Positive criterion Reference
MG-132 20 μM 24 hr rat PC12 cells Measurement of cytochrome c release using a solid-phase, enzyme-linked immunosorbent assay kit for the detection of cytochrome c. increase Positive 289
Flufenamic Acid 70 24hr rat hepatocytes cytochrome c release (anti-cytochrome c antibody ) induce Positive AC50 (μM) 40
Tolfenamic Acid 75 24hr rat hepatocytes cytochrome c release (anti-cytochrome c antibody ) induce Positive AC50 (μM) 40
Mefenamic acid 277 24hr rat hepatocytes cytochrome c release (anti-cytochrome c antibody ) induce Positive AC50 (μM) 40
Meloxicam 245 24hr rat hepatocytes cytochrome c release (anti-cytochrome c antibody ) induce Positive AC50 (μM) 40
Sudoxicam 282 24hr rat hepatocytes cytochrome c release (anti-cytochrome c antibody ) induce Positive AC50 (μM) 40
Piroxicam 598 24hr rat hepatocytes cytochrome c release (anti-cytochrome c antibody ) induce Positive AC50 (μM) 40
Diflunisal 79 24hr rat hepatocytes cytochrome c release (anti-cytochrome c antibody ) induce Positive AC50 (μM) 40
Diclofenac 197 24hr rat hepatocytes cytochrome c release (anti-cytochrome c antibody ) induce Positive AC50 (μM) 40
Sulindac sulfide 59 24hr rat hepatocytes cytochrome c release (anti-cytochrome c antibody ) induce Positive AC50 (μM) 40
Nimesulide 21 24hr rat hepatocytes cytochrome c release (anti-cytochrome c antibody ) induce Positive AC50 (μM) 40