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Drug

D0096 | Perhexiline

Molecular Formula C19H35N
Molecular Weight 277.5
Structure
State solid
Protein binding Perhexiline and its metabolites are highly protein bound (>90%).
Half life Variable and non-linear. Some reports show a half-life of 2-6 days, others indicate it could be as high as 30 days.
Absorption Well absorbed (>80%) from the gastrointestinal tract following oral administration.
Description prophylactic antianginal agent; coronary vasodilator

C

C08EX02 Perhexiline


[C08EX] Other non-selective calcium channel blockers


[C08E] NON-SELECTIVE CALCIUM CHANNEL BLOCKERS


[C08] CALCIUM CHANNEL BLOCKERS


[C] Cardiovascular system

Toxicity Dose Time Species Model Method Action Positive criterion Reference
ELECTROPHORETIC UNCOUPLING 278
MEMBRANE POTENTIAL 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of mitochondrial membrane potential decrease 193
MEMBRANE POTENTIAL 3.2 µM 30 mins mouse liver mitochondria Rh123 fluorescence (excitation 485 nm, emission 535 nm) are recorded using a fluorescence multi-well plate reader (mCICCP (20 µM) treatments was considered as the 100% baseline for ΔΨm loss) decrease EC20 36
RESPIRATION 88.4 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. decrease EC20 36
RESPIRATION 87.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. decrease EC20 36
STATE 3 RESPIRATION 50 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake Negative p < 0.05 193
STATE 3 RESPIRATION 100 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease p < 0.01 193
STATE 3 RESPIRATION 200 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease p < 0.01 193
STATE 3 RESPIRATION 400 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease p < 0.01 193
STATE 3 RESPIRATION 50 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake Negative p < 0.05 193
STATE 3 RESPIRATION 100 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease p < 0.05 193
STATE 3 RESPIRATION 200 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease p < 0.01 193
STATE 3 RESPIRATION 400 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease p < 0.01 193
STATE 3 RESPIRATION 200 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake Negative p < 0.05 193
STATE 3 RESPIRATION 200 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake Negative p < 0.05 193
STATE 4 RESPIRATION 50 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake Negative p < 0.05 193
STATE 4 RESPIRATION 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake increase p < 0.01 193
STATE 4 RESPIRATION 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake increase p < 0.01 193
STATE 4 RESPIRATION 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake Negative p < 0.05 193
STATE 4 RESPIRATION 50 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake Negative p < 0.05 193
STATE 4 RESPIRATION 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake increase p < 0.01 193
STATE 4 RESPIRATION 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake increase p < 0.01 193
STATE 4 RESPIRATION 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake Negative p < 0.05 193
ELECTRON TRANSPORT CHAIN affect 227
UNCOUPLED RESPIRATION 200 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake Negative p < 0.05 193
UNCOUPLED RESPIRATION 200 μM 5 minutes preincubation mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of oxygen uptake decrease p < 0.01 193
FATTY ACID METABOLISM 0.2 to 0.4 24hr MCF-7 and T47D cells quantifies the conversion of [9,10-3H(N)]-palmitic acid to 3H2O with diffusion Negative Student’s two-tail t-test, where p < 0.05 273
MITOCHONDRIAL FATTY ACID BETA OXIDATION 5 μM 72 hours rat; Sprague-Dawley Crl:CD-1 (ICR) BR hepatocytes Measurement of beta oxidation decrease p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 5 μM 24 hours rat; Sprague-Dawley Crl:CD-1 (ICR) BR hepatocytes Measurement of beta oxidation Negative p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 25 μM 24 hours rat; Sprague-Dawley Crl:CD-1 (ICR) BR hepatocytes Measurement of beta oxidation decrease p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 100 μM 5 minutes preincubation; 10 minutes mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of beta oxidation decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 100 μM 5 minutes preincubation; 10 minutes mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of beta oxidation decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 50 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 800 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 1200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 50 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 800 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 1200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 1600 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 50 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 800 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 1200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 1600 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases decrease p < 0.01 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activity of long-chain fatty acyl-CoA synthetase Negative p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activity of long-chain fatty acyl-CoA synthetase Negative p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activity of long-chain fatty acyl-CoA synthetase Negative p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activity of long-chain fatty acyl-CoA synthetase Negative p < 0.05 193
MITOCHONDRIAL FATTY ACID BETA OXIDATION decrease 16
MITOCHONDRIAL FATTY ACID BETA OXIDATION decrease 16
MITOCHONDRIAL FATTY ACID BETA OXIDATION decrease 17
MITOCHONDRIAL FATTY ACID BETA OXIDATION decrease 17
MITOCHONDRIAL FATTY ACID BETA OXIDATION decrease 35
MITOCHONDRIAL FATTY ACID BETA OXIDATION rat hepatocytes affect 238
MITOCHONDRIAL FATTY ACID BETA OXIDATION 77 μmol/L rat cardiac mitochondria CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine, affect IC50 240
MITOCHONDRIAL FATTY ACID BETA OXIDATION 148 μmol/L rat hepatic mitochondria CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine, affect IC50 240
MITOCHONDRIAL FATTY ACID BETA OXIDATION 22.4/21.4 human/rat hepatocytes Fatty acid oxidation (FAO) was determined by measuring 14CO2 release from 14C-labeled palmitate inhibition IC50 (μM) 333
SYNTHESIS OF KETONE BODY 14.8 Wistar rat hepatocytes ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) inhibition IC50 (μM) 333
TRANSPORT OF POTASSIUM decrease 16
TRANSPORT OF POTASSIUM decrease 16
SWELLING 14.8 µM 30 mins mouse liver mitochondria swelling assay: Absorbance at 545 nm using a fluorescence multi-well plate reader (CaCl2 (50 µM) was considered as the 100% baseline for the swelling ) increase EC20 36

Target Dose Time Species Model Method Action Positive criterion Reference
NADH:ubiquinone reductase 88.4 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition. inhibit EC20 36
Succinate dehydrogenase 87.7 µM 60 mins mouse liver mitochondria Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition. inhibit EC20 36
carnitine palmitoyltransferases I inhibitor 16
carnitine palmitoyltransferases I inhibitor 17
carnitine palmitoyltransferases I inhibitor 35
carnitine palmitoyltransferases I 77 μmol/L rat cardiac mitochondria CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine, inhibit IC50 240
carnitine palmitoyltransferases I 148 μmol/L rat hepatic mitochondria CPT-1 activity was measured by the formation of palmitoyl-[3H]-carnitine from palmitoyl-CoA and [3H]-I- carnitine, inhibit IC50 240
Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, EC 2.3.1.21 >100/− human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB Negative IC50 (μM) 333
Carnitine O-palmitoyltransferase 1, muscle isoform >100 human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB Negative IC50 (μM) 333
Carnitine O-palmitoyltransferase 2, mitochondrial, EC 2.3.1.21 inhibitor 16
Carnitine O-palmitoyltransferase 2, mitochondrial, EC 2.3.1.21 inhibitor 17
Carnitine O-palmitoyltransferase 2, mitochondrial, EC 2.3.1.21 72.8/− human/rat recombinant Pichia pastoris Membrane Preparations spectrophotometric assay with DTNB inhibition IC50 (μM) 333
Long-chain-fatty-acid--CoA ligase 1 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activity of long-chain fatty acyl-CoA synthetase Negative p < 0.05 193
Long-chain-fatty-acid--CoA ligase 1 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activity of long-chain fatty acyl-CoA synthetase Negative p < 0.05 193
Short-chain specific acyl-CoA dehydrogenase, mitochondrial 50 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Short-chain specific acyl-CoA dehydrogenase, mitochondrial 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Short-chain specific acyl-CoA dehydrogenase, mitochondrial 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Short-chain specific acyl-CoA dehydrogenase, mitochondrial 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.05 193
Short-chain specific acyl-CoA dehydrogenase, mitochondrial 800 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.01 193
Short-chain specific acyl-CoA dehydrogenase, mitochondrial 1200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.01 193
Short-chain specific acyl-CoA dehydrogenase, mitochondrial 1600 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.01 193
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 50 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.01 193
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.01 193
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 800 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.01 193
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 1200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.01 193
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 1600 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.01 193
Long-chain specific acyl-CoA dehydrogenase, mitochondrial 50 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Long-chain specific acyl-CoA dehydrogenase, mitochondrial 100 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases Negative p < 0.05 193
Long-chain specific acyl-CoA dehydrogenase, mitochondrial 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.01 193
Long-chain specific acyl-CoA dehydrogenase, mitochondrial 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.01 193
Long-chain specific acyl-CoA dehydrogenase, mitochondrial 800 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.01 193
Long-chain specific acyl-CoA dehydrogenase, mitochondrial 1200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activities of acyl-CoA dehydrogenases inhibitor p < 0.01 193
Medium-chain acyl-CoA ligase ACSF2, mitochondrial 200 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activity of long-chain fatty acyl-CoA synthetase Negative p < 0.05 193
Medium-chain acyl-CoA ligase ACSF2, mitochondrial 400 μM mouse; Crl/CD-l(1CR)BR Swiss liver mitochondria Measurement of activity of long-chain fatty acyl-CoA synthetase Negative p < 0.05 193
Potassium voltage-gated channel subfamily A member 5 inhibitor 16
hERG inhibitor 16
NADPH oxidase inhibit 20
Cytochrome c < 25 µM 30 mins mouse liver mitochondria Cytochrome c release was evaluated using ELISA kit ( 20 µg/ml Alamethicin was used as 100% baseline) release EC20 36

  • Coronary artery disease

  • Diabetes mellitus

    • (+)-2-(2,2-Dicyclohexylethyl)piperidine (-)-2-(2,2-Dicyclohexylethyl)piperidine (1)-2-(2,2-Dicyclohexylethyl)piperidine
    (?)-2-(2,2-Dicyclohexylethyl)piperidine (Z)-2-butenedioic acid;2-(2,2-dicyclohexylethyl)piperidine (Z)-but-2-enedioic acid;2-(2,2-dicyclohexylethyl)piperidine
    2-(2,2-Dicyclohexylethyl)piperidine 2-(2,2-dicyclohexylethyl)piperidine;maleic acid 2-[2,2-DICYCLOHEXYLETHYL]PIPERIDINE MALEATE SALT
    35193-73-8 39648-47-0 39648-48-1
    6621-47-2 AB00053656 AB00053656_22
    ACM39648470 ACM39648481 BDBM61402
    BPBio1_000212 BSPBio_000192 BSPBio_003118
    CHEBI:35553 CHEMBL75880 CTK1C5099
    CYXKNKQEMFBLER-UHFFFAOYSA-N D08340 DB01074
    DTXSID7023439 DivK1c_000542 EINECS 229-569-5
    EINECS 252-426-3 EINECS 254-558-7 EINECS 254-559-2
    IDI1_000542 KBio1_000542 KBio2_000353
    KBio2_002921 KBio2_005489 KBio3_002618
    KBioGR_000685 KBioSS_000353 LS-176505
    MCULE-1263095324 NCGC00018261-02 NCGC00018261-05
    NINDS_000542 Oprea1_365504 PERHEXILINE
    Perhexilene Perhexilina Perhexilina [INN-Spanish]
    Perhexiline (INN) Perhexiline [INN:BAN] Perhexilinum
    Perhexilinum [INN-Latin] Piperidine, 2-(2,2-dicyclohexylethyl)- Piperidine, 2-(2,2-dicyclohexylethyl)-, (2Z)-2-butenedioate (1:1)
    Prestwick0_000286 Prestwick1_000286 Prestwick2_000286
    Prestwick3_000286 Q1232737 SBI-0051794.P002
    SCHEMBL114894 SPBio_001358 SPBio_002411
    Spectrum2_001539 Spectrum3_001579 Spectrum4_000173
    Spectrum5_001084 Spectrum_000013 cid_5284439
    perhexilline

    DrugBank Name Perhexiline
    DrugBank DB01074
    CAS Number 10118-35-1, 35193-73-8, 39648-47-0, 39648-48-1, 6621-47-2, 6724-53-4
    PubChem Compound 4746
    KEGG Drug D08340
    PubChem.Substance 46504471
    ChEBI 35553
    PharmGKB PA130150436
    ChemSpider 4584
    BindingDB 61402.0
    TTD DAP000957
    Wikipedia Perhexiline

    1. Chan et al. (2005)