Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Metformin	5mM	30 minutes	mouse; C57BL/6J	isolated skeletal muscle mitochondria	Meassurement of alpha-ketoglutarate concentration; compared with MCF10A	affect	Positive	p < 0.05	172
Metformin	5mM	30 minutes	mouse; C57BL/6J	isolated skeletal muscle mitochondria	Meassurement of alpha-ketoglutarate concentration; compared with MCF10A	affect	Positive	p < 0.05	172
Metformin	5mM	30 minutes	mouse; C57BL/6J	isolated skeletal muscle mitochondria	Meassurement of succinate concentration	decrease	Positive	p < 0.05	172
Metformin	5mM	30 minutes	mouse; C57BL/6J	isolated skeletal muscle mitochondria	Meassurement of succinate concentration	decrease	Positive	p < 0.05	172
Fluoroacetate						affect	Positive		173
Rosiglitazone	1uM	24 and 48 hours	Murine	adipocytes	Citrate Synthase Activity	affect	Positive		179
Polymyxin B	1.6 μg/ml		Mycobacterium smegmatis	membrane-bound dehydrogenases		affect	Positive	IC50	76
nanaomycin a	31 μg/ml		Mycobacterium smegmatis	membrane-bound dehydrogenases		affect	Positive	IC50	76
oxaloacetate						affect	Positive		79
malate						affect	Positive		79
citrate						affect	Positive		79
fumarate						affect	Positive		79
Metformin	0.5mM	24 hours	human	MCF10A	Meassurement of citrate concentration; compared with MCF10A	affect	Positive	p < 0.05	172
Metformin	0.5mM	24 hours	human	MCF7	Meassurement of citrate concentration; compared with MCF10A	affect	Positive	p < 0.05	172
Metformin	0.5mM	24 hours	human	MCF10A	Meassurement of isocitrate concentration; compared with MCF10A	affect	Positive	p < 0.05	172
Metformin	0.5mM	24 hours	human	MCF7	Meassurement of isocitrate concentration; compared with MCF10A	affect	Positive	p < 0.05	172
Metformin	0.5mM	24 hours	human	MCF10A	Meassurement of alpha-ketoglutarate concentration; compared with MCF10A	affect	Positive	p < 0.05	172
Fluoroacetate							Positive		251
Metformin	0.5mM	24 hours	human	MCF7	Meassurement of alpha-ketoglutarate concentration; compared with MCF10A	affect	Positive	p < 0.05	172
Tianeptine	0.5 mM		mouse		The activity of the tricarboxylic acid cycle, assessed as the in vitro formation of [14C]CO2 from [1-14C]acetylcoenzyme A in vitro.	affect	Positive		237
tetracyclines			mouse	liver mitochondria	Tricarboxylic acid cycle activity was assessed by the in vitro formation of [14C]CO2 from [1-14C]acetylcoenzyme A by mouse liver mitochondria.	affect	Positive		236
Metformin	5mM	30 minutes	mouse; C57BL/6J	isolated skeletal muscle mitochondria	Meassurement of citrate concentration; compared with MCF10A	affect	Positive	p < 0.05	172
Metformin	5mM	30 minutes	mouse; C57BL/6J	isolated skeletal muscle mitochondria	Meassurement of citrate concentration; compared with MCF10A	affect	Positive	p < 0.05	172

F020301. generation of citrate
F020302. generation of isocitrate
F020303. generation of alpha-ketoglutarate
F020304. generation of succinate

T002009. Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
T091. Citrate synthase, mitochondrial
T092. Aconitate hydratase, mitochondrial
T101. Malate:quinone oxidoreductase
T106. citrate
T107. isocitrate
T108. alpha-ketoglutarate
T109. succinate