Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
lovastatin				C2C12 myoblasts		affect	Positive		180
Simvastatin				C2C12 myoblasts		affect	Positive		180
thiazolidinediones						decrease	Positive		35
thiazolidinediones						decrease	Positive		34
1h-benzimidazol-5-amine-2-4-aminophenyl	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-(Dimethylamino)-1,3-benzothiazol-6-ol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)amino]phenol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
7,8-Dihydroxy-4-methylcoumarin	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-Amino-2-(5-ethyl-benzooxazol-2-yl)-phenol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
(4-Methoxyphenyl)-[2-(p-anisidino)ethyl]amine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
3,3'-Diamino-4,4'-dihydroxydiphenyl Sulfone	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-(4-Hydroxy-1H-indol-3-yl)acetamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2,5-Bis(2-phenylacetamido)terephthalic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2,6-Dimethyl-5,12-dihydroindolo[3,2-d][1,3]benzodiazepine;hydrochloride	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-(4-{[(4,6-Dimethyl-2-pyrimidinyl)amino]sulfonyl}phenyl)-2,4-dimethoxybenzamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N'-(4-Methoxybenzyl)-N,N-dimethylbenzene-1,3-diamine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-(1,2,3,4-Tetrahydro-benzo[a]phenanthridin-5-yl)-benzene-1,2-diol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-Benzyl-4-methoxyaniline	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
Methyl 2-amino-4-ethyl-5-methylthiophene-3-carboxylate	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-(4-(4-Methyl-1-piperazinyl)phenyl)-9-acridinamine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-Chloro-N-(2-hydroxyphenyl)benzenesulfonamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-(4-Hydroxyphenyl)furan-2-carboxamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
(Z)-2-Cyano-3-(3-ethoxy-4-hydroxyphenyl)prop-2-enamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
(3-Bromo-4-hydroxyphenyl)[(4-chlorophenyl)sulfonyl]amine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-Chloro-6-methylindolo[1,2-c]quinazolin-12-amine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-(2,3-Dihydro-1H-benzo[f]cyclopenta[c]quinolin-4-yl)benzene-1,2-diol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
(5E)-5-(4-Hydroxybenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
8-Chloro-2,2-dimethyl-2,3-dihydro-1H-phenothiazin-4(10H)-one	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-[(3,4-Dimethylphenyl)sulfonyl]benzene-1,4-diol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-([4-(1H-Benzimidazol-2-yl)phenyl]amino)-4-oxobutanoic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
Ethyl 2-ethoxy-5-hydroxy-1H-indole-3-carboxylate	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-(1,2,3,4-Tetrahydrobenzo[a]phenanthridin-5-yl)benzene-1,3-diol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-(Cyclohexylmethyl)-4-methoxyaniline	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-(Furan-2-ylmethyl)-1,3-benzodioxol-5-amine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
5-Nitro-2-phenyl-1H-indole	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
8-Chloro-2,3-dihydro-1H-phenothiazin-4(10H)-one	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-(4-Bromophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-[2-(2-Aminophenyl)vinyl]-5,7-dimethylquinolin-8-ol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4,6-Dimethyl-2-phenyl-2H-pyrazolo[3,4-b]pyridin-3-ol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-Methoxy-2-[(4-piperidylpiperidyl)methyl]phenol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-(5-Isopropyl-1,3,4-thiadiazol-2-yl)-3-nitrobenzamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-Amino-6-ethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
(NE)-N-[[3-[[3-[(E)-hydroxyiminomethyl]-2,4,6-trimethylphenyl]methyl]-2,4,6-trimethylphenyl]methylidene]hydroxylamine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-(3-Fluorophenyl)-2,4,6-tri(propan-2-yl)benzenesulfonamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-(4-Hydroxy-3-methoxybenzylidene)-1H-indene-1,3(2H)-dione	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-Furancarboxamide, N-[[(4-methoxyphenyl)amino]thioxomethyl]-	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-Amino-N-quinolin-8-yl-benzenesulfonamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
(5Z)-5-[(4-Fluorophenyl)methylidene]-1-methyl-3-phenyl-1,3-diazinane-2,4,6-trione	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-[4-(1-Adamantyl)phenoxy]-N,N-diethylethanamine;hydrochloride	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
(2Z)-2-(Acetylamino)-N-(4-hydroxyphenyl)-3-phenylprop-2-enamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
(5E)-5-[(3-Bromo-4-methoxyphenyl)methylidene]-1-phenyl-2-sulfanylidene-1,3-diazinane-4,6-dione	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
[(3-{[(4-Bromophenyl)amino]carbonyl}phenyl)thio]acetic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-[(4-Chlorobenzyl)thio]-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
1-(5-Hydroxy-2-methyl-1-phenyl-1H-indol-3-yl)ethanone	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-[(4-Ethylpiperazin-1-yl)methyl]-4-methoxyphenol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-(4-Fluorophenyl)-1,3,5-trimethyl-2,6-diphenylpiperidin-4-ol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-[(E)-1-[5-(4-Bromophenyl)furan-2-yl]-3-[3-(dimethylamino)propylamino]-3-oxoprop-1-en-2-yl]-4-methylbenzamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
(2Z)-3-{N-[4-(4-Chlorophenyl)phenyl]carbamoyl}prop-2-enoic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-[(E)-3-(4-Ethylpiperazin-1-yl)prop-1-enyl]-N,N-dimethylaniline	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
1,5-Dihydro-4,5-diphenyl-2H-imidazol-2-one	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-[(E)-2-(4-Chlorophenyl)ethenyl]-1-methyl-1H-benzimidazole	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-[1-Azabicyclo[2.2.2]octan-3-ylidene-[4-(dimethylamino)phenyl]methyl]-N,N-dimethylaniline;hydrochloride	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-Oxo-4-((4-(styryl)phenyl)amino)but-2-enoic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2,5-Dianilinoterephthalic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-Methoxy-N-[4-(thiazol-2-ylsulfinamoyl)-phenyl]-benzamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
3-[(3,4-Dimethylphenyl)sulfonyl]propanenitrile	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-[4-(1,3-Benzoxazol-2-yl)anilino]-4-oxobutanoic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
1-(3-Chlorophenyl)-2,3,4,5,6,7,8,8a-octahydro-1H-isoquinolin-4a-ol;hydrochloride	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
6-Methyl-2-(1,2,2,2-tetrafluoroethyl)-1H-benzimidazole	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
Ethyl 6-amino-5-cyano-2-methyl-4-(2-nitrophenyl)-4H-pyran-3-carboxylate	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-(2,1,3-Benzoxadiazol-4-yl)-2,2,2-trifluoroacetamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-Tert-butyl-N-(4-methylphenyl)benzamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-Methoxy-4-(morpholin-4-ylmethyl)phenol	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
Bis((1E)-2-phenylvinyl)phosphinic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
1-[2-(Allyloxy)benzyl]-4-benzylpiperidine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2,5-Diaminoterephthalic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-(1-Adamantylcarbonyl)-N'-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)thiourea	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-(Isobutylthio)succinic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-{4-[Acetyl(methyl)amino]phenyl}-4-biphenylcarboxamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
4-[(E)-3-(2-Ethylpiperidin-1-yl)prop-1-enyl]-N,N-dimethylaniline	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
3-(2-Chloro-phenyl)-2-(4-(2-oxo-2H-chromen-3-YL)-thiazol-2-YL)-acrylonitrile	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
Ethyl (7Z)-2-amino-7-(hydroxyimino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-Amino-4-(3,4-dichlorophenyl)thiazole	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
5-(2-Nitrobenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
3-(4-Bromo-2-thienyl)-2-cyano-2-propenethioamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
Benzyl [(6-amino-3,5-dicyano-4-ethylpyridin-2-yl)sulfanyl]acetate	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
N-{2-[(1,3-Diphenyl-1H-pyrazol-5-yl)amino]phenyl}benzamide	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-Butyl-5-methylisophthalic acid	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-Butylsulfanyl-6-methyl-9H-1,3,4,9-tetraaza-fluorene	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
2-Phenyldipyrrolo[1,2-a:2',1'-c]pyrazine	∼2.5 µM		rat	skeletal muscle mitochondria	measurement of superoxide/H2O2 production	affect	Positive		162
Valproic Acid	0.5–2 mM	3min	rat	inverted submitochondrial vesicles (ISMV) from rat liver isolated mitochondria	The rate of the radiolabeled substrate [1-14C]-pyruvate uptake by ISMV was measured in the presence or absence of an inwardly directed proton gradient.	inhibitor	Positive		279
alpha-Cyano-4-hydroxycinnamate	1mM	3min	rat	inverted submitochondrial vesicles (ISMV) from rat liver isolated mitochondria	The rate of the radiolabeled substrate [1-14C]-pyruvate uptake by ISMV was measured in the presence or absence of an inwardly directed proton gradient.	inhibitor	Positive		279
alpha-Cyano-4-hydroxycinnamate	0.05mM					inhibitor	Positive	>90% inhibition	280
Alpha-Cyanocinnamate	0.05mM					inhibitor	Positive	>90% inhibition	280

F02110102. malate asparatate shuttle
F02110103. s,n-glycerophosphate shuttle
F02110104. transport of glutamate
F02110105. transport of dicarboxylate
F02110106. transport of 2-oxoglutarate
F02110107. carnitine shuttle
F02110108. transport of tricarboxylate
F02110109. transport of ornithine/citrulline
F02110110. transport of deoxynucleotide
F02110111. transport of L-aspartic acid
F02110112. transport of pyruvate
F02110113. transport of monocarboxylate
F02110114. transport of citrate
F02110115. transport of glucose
F02110116. transport of fatty acid

T084. Mitochondrial pyruvate carrier 1
T181. Glycerol-3-phosphate dehydrogenase, mitochondrial
T195. Mitochondrial pyruvate carrier