F030803 | Fusion
| Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Teriflunomide | induce | Positive | 295 | ||||||
| Leflunomide | 50 μM | 48 hr | HeLa cells, C2C12 muscle cells, MEF cells | Mfn2 and Mfn1 mRNA levels; MFN2, MFN1, and porin protein levels; images of mitochondrial morphology ; | induce | Positive | 295 | ||
| colchicine | Positive | 185 | |||||||
| docetaxel | Positive | 185 | |||||||
| BGP-15 | 50 μM | 4hr | WRL-68 cells | Polyethylene glycol (PEG) fusion assay; OPA1 GTPase assay and OPA1-OPA1 interactions | induce | Positive | 297 | ||