F02060201 | Synthesis of ketone body
GO:0046951
map00072
R-HSA-77111
Function of mitochondria >> Lipid metabolism >> Ketone body metabolism >> Synthesis of ketone body
Function of mitochondria >> Lipid metabolism >> Ketone body metabolism >> Synthesis of ketone body
| Compound | Dose | Time | Species | Model | Method | Action | Result | Positive criterion | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Amiodarone | 34 μmol/L | rat; Sprague–Dawley | liver mitochondria | Measurement of beta oxidation and ketone body formation | decrease | Positive | IC50 | 4 | |
| benzarone | 34 μmol/L | rat; Sprague–Dawley | liver mitochondria | Measurement of beta oxidation and ketone body formation | decrease | Positive | IC50 | 4 | |
| benzbromarone | 2 μmol/L | rat; Sprague–Dawley | liver mitochondria | Measurement of beta oxidation and ketone body formation | decrease | Positive | IC50 | 4 | |
| 2‐Butylbenzofuran | 100 μmol/L | rat; Sprague–Dawley | liver mitochondria | Measurement of beta oxidation and ketone body formation | decrease | Positive | 28% inhibition | 4 | |
| TDGA | 0.31 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| POCA | 59.7 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| Etomoxir | 2.76 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| DET | 5.6 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| aminocarnitine | 0.97 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| palmitoylaminocarnitine | 0.11 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| ST1326 | 1.1 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| ST2425 | 0.21 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| Trimetazidine | 47.1 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| Perhexiline | 14.8 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| Amiodarone | 16.6 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| Oxfenicine | >100 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| oxfenicine metabolite | 25.8 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |
| RO-25-0187 | 1.5 | Wistar rat | hepatocytes | ketone bodies (KB = β-hydroxybutyrate + acetoacetate) were determined with a commercially available kit (Autokit 3-HB from Wako) | inhibition | Positive | IC50 (μM) | 333 | |