GO:0006749 map00480 R-HSA-174403
Function of mitochondria >> glutathione metabolism

Related Drugs/Compounds

Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Troglitazone	10 µM		ZDF fa/fa rat vs ZDF lean rat	isolated mitochondria	Measurement of reduced/oxidized glutathione (GSH/GSSG): the reduced/oxidized glutathione (GSH/GSSG) concentration of the samples was determined from a standard curve using the enzymatic method and a Multiskan JX system.	lower	Positive	significantly different from ZDF lean rats (p < 0.05).	225
Flufenamic Acid	79	24hr	rat	hepatocytes	glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342		Positive	AC50 (μM)	40
Tolfenamic Acid	105	24hr	rat	hepatocytes	glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342		Positive	AC50 (μM)	40
Mefenamic acid	148	24hr	rat	hepatocytes	glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342		Positive	AC50 (μM)	40
Meloxicam	316	24hr	rat	hepatocytes	glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342		Positive	AC50 (μM)	40
Sudoxicam	313	24hr	rat	hepatocytes	glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342		Positive	AC50 (μM)	40
Diflunisal	29	24hr	rat	hepatocytes	glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342		Positive	AC50 (μM)	40
Diclofenac	167	24hr	rat	hepatocytes	glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342		Positive	AC50 (μM)	40
Sulindac	896	24hr	rat	hepatocytes	glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342		Positive	AC50 (μM)	40
Sulindac sulfide	40	24hr	rat	hepatocytes	glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342		Positive	AC50 (μM)	40
Nimesulide	1	24hr	rat	hepatocytes	glutathion depletion: cells were incubated with 50 μM monochlorobimane with 6 μg/ml Hoechst 33342		Positive	AC50 (μM)	40
MG-132	20 μM	24 hr	rat	PC12 cells	The total glutathione (reduced form GSH + oxidized form GSSG) was determined using glutathione reductase	deplete GSH	Positive		289
3-morpholinosydnonimine	150 μM	24 hr	rat	PC12 cells	The total glutathione (reduced form GSH + oxidized form GSSG) was determined using glutathione reductase	restore GSH	Positive		289
Acetaminophen	1 g/kg	6 hours	mice; C57Bl/6	in vivo	GSH level measurement	increase	Positive	p < 0.05	1
Acetaminophen	1 g/kg	12 hours	mice; C57Bl/6	in vivo	GSH level measurement	increase	Positive	p < 0.05	1
Acetaminophen	1 g/kg	24 hours	mice; C57Bl/6	in vivo	GSH level measurement	increase	Positive	p < 0.05	1

Involved Pathways

F022101. GSH content
F022102. GSSH/GHS ratio