Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Fluorouracil	0.5 - 800 μM			Colo320; DLD1; HT29; LoVo; SW480		increase	Positive		164
Nimesulide	8	24hr	rat	hepatocytes	DNA damage 153 induction (GADD153 antibodies) for ER-stress induced apoptosis	induce	Positive	AC50 (μM)	40
Bafilomycin A1				pediatric B ALL cells		induce	Positive		200
Bafilomycin A1						induce	Positive		200
FOX-988						increase	Positive		28
Sdz-51641						increase	Positive		28
Flufenamic Acid	68	24hr	rat	hepatocytes	DNA damage 153 induction (GADD153 antibodies) for ER-stress induced apoptosis	induce	Positive	AC50 (μM)	40
Tolfenamic Acid	50	24hr	rat	hepatocytes	DNA damage 153 induction (GADD153 antibodies) for ER-stress induced apoptosis	induce	Positive	AC50 (μM)	40
Mefenamic acid	61	24hr	rat	hepatocytes	DNA damage 153 induction (GADD153 antibodies) for ER-stress induced apoptosis	induce	Positive	AC50 (μM)	40
Meloxicam	153	24hr	rat	hepatocytes	DNA damage 153 induction (GADD153 antibodies) for ER-stress induced apoptosis	induce	Positive	AC50 (μM)	40
Sudoxicam	223	24hr	rat	hepatocytes	DNA damage 153 induction (GADD153 antibodies) for ER-stress induced apoptosis	induce	Positive	AC50 (μM)	40
Piroxicam	610	24hr	rat	hepatocytes	DNA damage 153 induction (GADD153 antibodies) for ER-stress induced apoptosis	induce	Positive	AC50 (μM)	40
Diflunisal	50	24hr	rat	hepatocytes	DNA damage 153 induction (GADD153 antibodies) for ER-stress induced apoptosis	induce	Positive	AC50 (μM)	40
Troglitazone			human	hepatocytes	cell viability assay	induce	Positive		226
Diclofenac	51	24hr	rat	hepatocytes	DNA damage 153 induction (GADD153 antibodies) for ER-stress induced apoptosis	induce	Positive	AC50 (μM)	40
Sulindac sulfide	53	24hr	rat	hepatocytes	DNA damage 153 induction (GADD153 antibodies) for ER-stress induced apoptosis	induce	Positive	AC50 (μM)	40
Flufenamic Acid	70	24hr	rat	hepatocytes	cytochrome c release (anti-cytochrome c antibody )	induce	Positive	AC50 (μM)	40
apoptolidin	18 μM			60 human cancer cell lines of the National Cancer Institute			Positive	mean	184
cytovaricin	1 μM			60 human cancer cell lines of the National Cancer Institute			Positive	mean	184
Oligomycin	0.3 μM			60 human cancer cell lines of the National Cancer Institute			Positive	mean	184
Tolfenamic Acid	75	24hr	rat	hepatocytes	cytochrome c release (anti-cytochrome c antibody )	induce	Positive	AC50 (μM)	40
Mefenamic acid	277	24hr	rat	hepatocytes	cytochrome c release (anti-cytochrome c antibody )	induce	Positive	AC50 (μM)	40
Meloxicam	245	24hr	rat	hepatocytes	cytochrome c release (anti-cytochrome c antibody )	induce	Positive	AC50 (μM)	40
Sudoxicam	282	24hr	rat	hepatocytes	cytochrome c release (anti-cytochrome c antibody )	induce	Positive	AC50 (μM)	40
Piroxicam	598	24hr	rat	hepatocytes	cytochrome c release (anti-cytochrome c antibody )	induce	Positive	AC50 (μM)	40
Diflunisal	79	24hr	rat	hepatocytes	cytochrome c release (anti-cytochrome c antibody )	induce	Positive	AC50 (μM)	40
Diclofenac	197	24hr	rat	hepatocytes	cytochrome c release (anti-cytochrome c antibody )	induce	Positive	AC50 (μM)	40
Sulindac sulfide	59	24hr	rat	hepatocytes	cytochrome c release (anti-cytochrome c antibody )	induce	Positive	AC50 (μM)	40
Nimesulide	21	24hr	rat	hepatocytes	cytochrome c release (anti-cytochrome c antibody )	induce	Positive	AC50 (μM)	40
Amiodarone	100 μmol/L	8 hours	human	HepG2	Assessment of cytochrome c release	increase	Positive	observable	4
benzarone	100 μmol/L	8 hours	human	HepG2	Assessment of cytochrome c release	increase	Positive	observable	4
benzbromarone	100 μmol/L	8 hours	human	HepG2	Assessment of cytochrome c release	increase	Positive	observable	4
Amiodarone	100 μmol/L	8 hours	rat; Sprague–Dawley	hepatocytes	Apoptosis measurement	increase	Positive	p < 0.01	4
benzarone	100 μmol/L	8 hours	rat; Sprague–Dawley	hepatocytes	Apoptosis measurement	increase	Positive	p < 0.01	4
benzbromarone	100 μmol/L	8 hours	rat; Sprague–Dawley	hepatocytes	Apoptosis measurement	increase	Positive	p < 0.01	4
Amiodarone	100 μmol/L	8 hours	rat; Sprague–Dawley	hepatocytes	Apoptosis measurement	increase	Positive	p < 0.05	4
benzarone	100 μmol/L	8 hours	rat; Sprague–Dawley	hepatocytes	Apoptosis measurement	increase	Positive	p < 0.05	4
benzbromarone	100 μmol/L	8 hours	rat; Sprague–Dawley	hepatocytes	Apoptosis measurement	increase	Positive	p < 0.01	4
Clotrimazole	30 μmol/L	24 hours	human	CAL27	Apoptosis measurement	increase	Positive	p < 0.05	5
Clotrimazole	30 μmol/L	24 hours	human	SCC25	Apoptosis measurement	increase	Positive	p < 0.05	5
Clotrimazole	30 μmol/L	24 hours	human	UM1	Apoptosis measurement	increase	Positive	p < 0.05	5
Clotrimazole	40 μmol/L	24 hours	human	CAL27	Apoptosis measurement	increase	Positive	p < 0.01	5
Clotrimazole	40 μmol/L	24 hours	human	SCC25	Apoptosis measurement	increase	Positive	p < 0.01	5
Clotrimazole	40 μmol/L	24 hours	human	UM1	Apoptosis measurement	increase	Positive	p < 0.01	5
Clotrimazole	30 μmol/L	24 hours	human	CAL27	Apoptosis measurement	increase	Positive	p < 0.05	5
Etoposide				isolated mitochondria		increase	Positive		57
Clotrimazole	30 μmol/L	24 hours	human	SCC25	Apoptosis measurement	increase	Positive	p < 0.05	5
Clotrimazole	30 μmol/L	24 hours	human	UM1	Apoptosis measurement	increase	Positive	p < 0.05	5
Clotrimazole	40 μmol/L	24 hours	human	CAL27	Apoptosis measurement	increase	Positive	p < 0.01	5
Clotrimazole	40 μmol/L	24 hours	human	SCC25	Apoptosis measurement	increase	Positive	p < 0.01	5
Clotrimazole	40 µM	12 hours	human	CAL27	western blot	increase	Positive	2.1875-fold decrease	5
Clotrimazole	40 µM	12 hours	human	UM1	western blot	increase	Positive	1.35-fold decrease	5
Clotrimazole	40 µM	24 hours	human	CAL27	western blot	increase	Positive	3.1818-fold decrease	5
Clotrimazole	40 µM	24 hours	human	UM1	western blot	increase	Positive	1.5-fold decrease	5
Clotrimazole	40 µM	48 hours	human	CAL27	western blot	increase	Positive	3.3333-fold decrease	5
Clotrimazole	40 µM	48 hours	human	UM1	western blot	increase	Positive	1.5882-fold decrease	5
Clotrimazole	40 µM	12 hours	human	CAL27	western blot	increase	Positive	1.3953-fold increase	5
Clotrimazole	40 µM	24 hours	human	CAL27	western blot	increase	Positive	1.3953-fold increase	5
Clotrimazole	40 µM	24 hours	human	UM1	western blot	increase	Positive	1.2623-fold increase	5
Clotrimazole	40 µM	48 hours	human	CAL27	western blot	increase	Positive	2.3256-fold increase	5
Clotrimazole	40 µM	48 hours	human	UM1	western blot	increase	Positive	1.6223-fold increase	5
Clotrimazole	150 mg/kg/day	6 days a week for two weeks	human	CAL27(xenograft tumors)/mouse	Immunohistochemistry	increase	Positive	1.5-fold decrease	5
Clotrimazole	150 mg/kg/day	6 days a week for two weeks	human	CAL27(xenograft tumors)/mouse	western blot analysis	increase	Positive	2.0-fold increase	5
p,p'-ddt	30 μM		rat	Sertoli cells		induce	Positive		242
Rotenone	0.1–0.5 nmol/mg protein			Wistar rat brain isolated mitochondria			Positive		242
N-deacetyl ketoconazole	120 μM	0.5 hours	rat	hepatocytes	Measurement of LDH activities	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	160 μM	0.5 hours	rat	hepatocytes	Measurement of LDH activities	increase	Positive	p < 0.05	8
mimosine	0.3 mM			U-937 leukemia cell line.			Positive		270
N-deacetyl ketoconazole	120 μM	1 hours	rat	hepatocytes	Measurement of LDH activities	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	160 μM	1 hours	rat	hepatocytes	Measurement of LDH activities	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	80 μM	2 hours	rat	hepatocytes	Measurement of LDH activities	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	120 μM	2 hours	rat	hepatocytes	Measurement of LDH activities	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	160 μM	2 hours	rat	hepatocytes	Measurement of LDH activities	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	60 μM	4 hours	rat	hepatocytes	Measurement of LDH activities	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	80 μM	4 hours	rat	hepatocytes	Measurement of LDH activities	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	120 μM	4 hours	rat	hepatocytes	Measurement of LDH activities	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	160 μM	4 hours	rat	hepatocytes	Measurement of LDH activities	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	120 μM	0.5 hours	rat	hepatocytes	Measurement of LDH activities; co-treatment of 250 μM n-Octylamine	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	120 μM	0.5 hours	rat	hepatocytes	Measurement of LDH activities; co-treatment of 100 μM Methimazole	affect	Positive	p < 0.05	8
N-deacetyl ketoconazole	120 μM	1 hours	rat	hepatocytes	Measurement of LDH activities; co-treatment of 250 μM n-Octylamine	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	120 μM	1 hours	rat	hepatocytes	Measurement of LDH activities; co-treatment of 100 μM Methimazole	affect	Positive	p < 0.05	8
N-deacetyl ketoconazole	160 μM	1 hours	rat	hepatocytes	Measurement of LDH activities; co-treatment of 250 μM n-Octylamine	increase	Positive	p < 0.05	8
N-deacetyl ketoconazole	160 μM	1 hours	rat	hepatocytes	Measurement of LDH activities; co-treatment of 100 μM Methimazole	affect	Positive	p < 0.05	8
Clotrimazole	40 μmol/L	24 hours	human	UM1	Apoptosis measurement	increase	Positive	p < 0.01	5
oxaliplatin							Positive		262
MG-132	20 μM	24 hr	rat	PC12 cells	Measurement of caspase-3 activity with ApoAlert™ CPP32/Caspase-3 assay kit	increase	Positive		289
MG-132	20 μM	24 hr	rat	PC12 cells	Measurement of cytochrome c release using a solid-phase, enzyme-linked immunosorbent assay kit for the detection of cytochrome c.	increase	Positive		289
Troglitazone	100 µM	24hr		HepG2 cells	Apo-One homogeneous caspase 3 assay kit		Positive		330
Niclosamide						induce	Positive		294
Dequalinium Chloride		24 hr		Ishikawa and Caco-2	WB was performed to measure the BCL-XL and released cytochrome c proteins from mitochondria; Caspase-3/7 activity was measured using the Caspase-Glo 3/7 reagent from the ApoTox-Glo Triplex Assay kit	induce	Positive		299
Cisplatin		24 hr		Ishikawa and Caco-2	WB was performed to measure the BCL-XL and released cytochrome c proteins from mitochondria; Caspase-3/7 activity was measured using the Caspase-Glo 3/7 reagent from the ApoTox-Glo Triplex Assay kit	induce	Positive		299
Cadmium	100, 500 μM	30 min	rat	PC12 cells	measured spectrofluorometrically using the fluorescent dye dichlorodihydrofluorescein diacetate (DCFH2-DA) as the ROS-sensitive probe	induce	Positive		300
Mercury	10-500 μM	30min	rat	PC12 cells	measured spectrofluorometrically using the fluorescent dye dichlorodihydrofluorescein diacetate (DCFH2-DA) as the ROS-sensitive probe	induce	Positive		300
Copper	10-500 μM	3hr	rat	PC12 cells	measured spectrofluorometrically using the fluorescent dye dichlorodihydrofluorescein diacetate (DCFH2-DA) as the ROS-sensitive probe	induce	Positive		300
Copper	500 μM	24 hr	rat	PC12 cells	measured spectrofluorometrically using the fluorescent dye dichlorodihydrofluorescein diacetate (DCFH2-DA) as the ROS-sensitive probe	induce	Positive		300

F070101. early apoptosis
F070102. late apoptosis
F070103. p53 pathway
F070104. caspase activity
F070105. cytochrome c release
F070106. ER stress-induced

T076. Lactate dehydrogenase
T403. Apoptosis regulator Bcl-2
T404. Apoptosis regulator BAX
T408. Cytochrome c
T409. Caspase-3
T411. Apoptosis-inducing factor 1, mitochondrial