Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Mdivi-1						inhibitor	Positive		296
Mdivi-1							Positive		248
Urolithin A						enhance	Positive		248
Ozone	1 μg O 3/mL			HeLa cells			Positive		247
Ozone	10 μg O 3/mL			HeLa cells			Positive		247
Nicotine	10 mM		Human	Human embryonal carcinoma cells (NT2/D1)			Positive		247
Cisplatin	3 mg/kg bodyweight	twice a week for 2 weeks	Mouse	Mouse tibial nerves and dorsal root ganglia (L1–L4)			Positive		247
Doxorubicin	7.2 μM DXR for 24 hrs		Human	fibroblasts			Positive		247
MDMA	20 μM MDMA mixture for 24 hrs			Mouse primary hippocampal neurons			Positive		247
Metamfetamine	0.5, 1, 2 mM Meth for 24 hrs			Human neuroblastoma SH- SY5Y			Positive		247
Perfluorooctanoic acid	In utero exposure (GD 1–17) to 1 mg/kg bodyweight dam			Post-natal day 91 mouse livers			Positive		247
Cadmium	In vitro: 12uM CdCl2 In vivo: 2mg/kg CdCl2			Rat hepatocytes			Positive		247
Manganese	Infusion of 1 μM MnCl2			Rat glia			Positive		247
Methylmercury	20 μM			Human HepG2 cells			Positive		247
Chlorpyrifos	30 μM			Human stem cell-derived neural progenitor cells			Positive		247
2,4-dinitrophenol	50 μM DNP at 3 hours post fertilization (hpf)			Danio rerio			Positive		247
CCCP	20 μM CCCP for 1 to 3 hours			HeLa cells			Positive		247
FCCP	10 μM FCCP for 48 to 72 hours			HeLa cells			Positive		247
Ultraviolet B	100 mJ/cm2		human	Normal epidermal keratinocytes			Positive		247
Ultraviolet C	60 mJ/cm2		Mouse	embryonic fibroblasts			Positive		247
XCT790						inhibit	Positive		308
Rosiglitazone		1, 2, 4, 7, 24, and 48 hrs	Murine	differentiated 3T3-L1 and C3H/10T1/2 adipocytes		increase	Positive		179
Wortmannin	100 nM			SH-SY5Y neuroblastoma cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
hydroxychloroquine	30 μM			SH-SY5Y neuroblastoma cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
3-methyladenine	10 mM			SH-SY5Y neuroblastoma cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
Bafilomycin A1	50 nM			SH-SY5Y neuroblastoma cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
CCCP	10 μM or 25 μM			mouse embryonic fibroblasts (MEFs) and SH-SY5Y cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.		Positive		252
earle’s balanced salt solution							Positive		252
rapamycin			mouse	embryonic retinas	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye		Positive		252
Cyclosporin A	5 μM			mouse embryonic fibroblasts (MEFs) and SH-SY5Y cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye	block	Positive		252
Nicotinamide	5 mM	6h		SH-SY5Y cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.	induce	Positive		252
fisetin	10 μM	6h		SH-SY5Y cells	Mitochondrial population levels were determined by flow cytometry using MitoTracker Deep Red (MTDR) dye.	induce	Positive		252
Xanthohumol	30μM	24hr		MCF7 cells	using the MAP1LC3II/I ratio to monitor the autophagic flux; quantifiedPMPCB staining	block	Positive		283
sertraline						decrease	Positive		307
Fluoxetine						decrease	Positive		307
quercetin				HepG			Positive		263
quercetin				brain			Positive		265
colchicine							Positive		185
Teriflunomide						induce	Positive		295
Leflunomide	50 μM	48 hr		HeLa cells, C2C12 muscle cells, MEF cells	Mfn2 and Mfn1 mRNA levels; MFN2, MFN1, and porin protein levels; images of mitochondrial morphology ;	induce	Positive		295
Chlorpyrifos	30 μM		Human	Human induced pluripotent stem cells (iPSCs)		increase	Positive		242
docetaxel							Positive		185
BGP-15	50 μM	4hr		WRL-68 cells	Polyethylene glycol (PEG) fusion assay; OPA1 GTPase assay and OPA1-OPA1 interactions	induce	Positive		297
piceatannol		48hr		Mfn1−/− MEFs stably expressing an Mfn1 promoter reporter construct	Relative luciferase activity was determined in Mfn1−/− MEFs carrying the Mfn1 promoter reporter		Positive		276

F030801. mitophagy
F030802. biogenesis
F030803. fusion
F030804. fission

T118. Peptidyl-prolyl cis-trans isomerase F, mitochondrial
T251. Dihydroorotate dehydrogenase
T260. Prohibitin-2
T358. Dynamin-1-like protein
T363. Dynamin-like 120 kDa protein, mitochondrial
T416. Serine/threonine-protein kinase mTOR
T419. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
T489. Mitofusin-1