Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Pioglitazone						decrease	Positive		22
Chlorpromazine			rat	isolated liver mitochondria		decrease	Positive		23
Haloperidol			rat	isolated liver mitochondria		decrease	Positive		23
Risperidone			rat	isolated liver mitochondria		decrease	Positive		23
quetiapine			rat	isolated liver mitochondria		decrease	Positive		23
Antimycin A						decrease	Positive		26
Myxothiazol			bovine	heart mitochondria		decrease	Positive		29
Papaverine						decrease	Positive		30
Thenoyltrifluoroacetone						decrease	Positive		33
Acetaminophen						decrease	Positive		35
Acetaminophen						decrease	Positive		35
Acetylsalicylic acid						decrease	Positive		35
Acetylsalicylic acid						decrease	Positive		35
Flutamide						decrease	Positive		35
Ketoconazole						decrease	Positive		35
mefloquine						decrease	Positive		35
Metformin						decrease	Positive		35
Nefazodone						decrease	Positive		35
Nitrofurantoin						decrease	Positive		35
Paraquat						decrease	Positive		35
paroxetine						decrease	Positive		35
paroxetine						decrease	Positive		35
paroxetine						decrease	Positive		35
paroxetine						decrease	Positive		35
Phenformin						decrease	Positive		35
Pioglitazone						decrease	Positive		35
Pioglitazone						decrease	Positive		35
promethazine						decrease	Positive		35
Rosiglitazone						decrease	Positive		35
Rotenone						decrease	Positive		35
Tamoxifen						decrease	Positive		35
Tamoxifen						decrease	Positive		35
Tamoxifen						decrease	Positive		35
Tamoxifen						decrease	Positive		35
Troglitazone						decrease	Positive		35
Antimycin A						decrease	Positive		35
Myxothiazol						decrease	Positive		35
Oligomycin						decrease	Positive		35
Thenoyltrifluoroacetone						decrease	Positive		35
alpidem						decrease	Positive		36
Amiodarone						decrease	Positive		36
benzbromarone						decrease	Positive		37
Chlorpromazine						decrease	Positive		7
clomipramine						decrease	Positive		38
Diclofenac						decrease	Positive		39
Flutamide						decrease	Positive		41
Ketoconazole						decrease	Positive		36
lovastatin						decrease	Positive		36
Phenformin						decrease	Positive		43
Rosiglitazone						decrease	Positive		7
Simvastatin						decrease	Positive		7
sitaxsentan						decrease	Positive		44
Tamoxifen						decrease	Positive		46
Troglitazone						decrease	Positive		7
Doxorubicin						decrease	Positive		36
imipramine						decrease	Positive		36
sertraline						decrease	Positive		48
zoniporide						decrease	Positive		50
pentamidine						decrease	Positive		51
ritonavir						decrease	Positive		36
Tenofovir						decrease	Positive		52
Polymyxin B			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
beclomethasone			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
bicalutamide			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
danazol			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
ethynodiol diacetate			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
retinoic acid			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
aripiprazole			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
axitinib			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
clofilium			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
tenidap			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
darifenacin			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
pimozide			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
Gemfibrozil				isolated mitochondria		decrease	Positive		7
Amitriptyline			pig	brain mitochondria		decrease	Positive		60
citalopram			pig	brain mitochondria		decrease	Positive		62
citalopram			pig	brain mitochondria		decrease	Positive		62
citalopram			pig	brain mitochondria		decrease	Positive		62
Haloperidol						decrease	Positive		23
propranolol			pig	brain mitochondria		decrease	Positive		60
Indomethacin			rat	isolated liver mitochondria		decrease	Positive		65
ochratoxin a			rat	isolated liver mitochondria		decrease	Positive		66
tacrolimus			rat	isolated kidney mitochondria		decrease	Positive		68
Piericidin A						affect	Positive		53
rolliniastatin-2						affect	Positive		53
Idebenone						affect	Positive		53
Rotenone						affect	Positive		53
piericidin a						affect	Positive		53
piericidin b						affect	Positive		53
aureothin						affect	Positive		53
amytal						affect	Positive		53
4-alkyl-acridones						affect	Positive		53
4′-alkyl-mpp+ analoguesc						affect	Positive		53
phenoxan						affect	Positive		53
quinol products						affect	Positive		53
reduced q-2b						affect	Positive		53
Myxothiazol						affect	Positive		53
stigmatellin						affect	Positive		53
TDS						affect	Positive		53
2M-TIO						affect	Positive		53
meperidine						affect	Positive		53
para-nonylphenol						affect	Positive		53
Diphenyleneiodonium chloride						affect	Positive		69
ethoxyformic anhydride						affect	Positive		70
ethoxyformic anhydride						decrease	Positive		70
ethoxyformic anhydride						decrease	Positive		70
flutolanil						affect	Positive		71
atpenin a5						affect	Positive		71
Carboxin						affect	Positive		71
penthiopyrad						affect	Positive		71
boscalid						affect	Positive		71
fluopyram						affect	Positive		71
dinitrophenol-17						affect	Positive		71
atpenin a5						affect	Positive		72
thiophene carboxamides						affect	Positive		73
HQNO						affect	Positive		74
Polymyxin B	1.6 μg/ml		Mycobacterium smegmatis	membrane-bound dehydrogenases		decrease	Positive	IC50	76
nanaomycin a	31 μg/ml		Mycobacterium smegmatis	membrane-bound dehydrogenases		decrease	Positive	IC50	76
siccanin			P. aeruginosa	PAO1 cells		affect	Positive		76
cyenopyrafen						affect	Positive		77
pyflubumide						affect	Positive		77
3-Nitropropionate						affect	Positive		78
Malonate						affect	Positive		79
british anti-lewisite						affect	Positive		80
Myxothiazol						affect	Positive		81
moas						affect	Positive		82
azoxystrobin						affect	Positive		83
oudemansin a						affect	Positive		84
strobilurin a						affect	Positive		84
cpmb-oxime						affect	Positive		84
azoxystrobin	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect	Positive		83
famoxadone	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect	Positive		83
stigmatellin	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect	Positive		83
uhdbt	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect	Positive		83
hhdbt uhnq	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect	Positive		83
dibromothymoquinone	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect	Positive		83
Antimycin A			bovine	isolated heart mitochondria cytochrome bc1 complex		affect	Positive		166
diuron						affect	Positive		83
NQNO			bovine	isolated heart mitochondria cytochrome bc1 complex		affect	Positive		166
NQNO			bovine	isolated heart mitochondria cytochrome bc1 complex		affect	Positive		166
Carbon Monoxide						affect	Positive		167
nitric oxide						affect	Positive		167
Cyanide						affect	Positive		167
azides						affect	Positive		167
sulfide						affect	Positive		167
formate						affect	Positive		167
ethylxanthate						affect	Positive		167
bisulfate						affect	Positive		167
semicarbazide						affect	Positive		167
salicyaldoxime						affect	Positive		167
ethylxanthate						decrease	Positive		167
bisulfate						decrease	Positive		167
semicarbazide						decrease	Positive		167
salicyaldoxime						decrease	Positive		167
adda 5			human	U251 mitochondria	CcO activity assay	affect	Positive		168
tetrathiomolybdate	30 μM	48 hour	human	ECC-1		affect	Positive		169
tetrathiomolybdate	30 μM	48 hour	human	IGROV-1		affect	Positive		169
Oligomycin	152 μg inhibitor/mg protein		E. coli	membrane vesicle, pH gradient formation		affect	Positive		170
Oligomycin	7.1 μg inhibitor/mg protein		C. asciculate	SMP-ATPase		affect	Positive	IC50	170
Oligomycin	2.0-3.0 μg inhibitor/mg protein		S. cerevisiae	SMP-ATPase		affect	Positive	IC50	170
Oligomycin	0.3 μM		human NCI-60 cell lines	F0F1-ATPase		affect	Positive	IC50	170
Oligomycin	15 ng inhibitor/mg protein		N. crassa	SMP-ATPase		affect	Positive	Ki	170
Oligomycin	0.21 μM		bovine	heart MF0F1-ATPase		affect	Positive	Ki	170
Oligomycin	0.4 μg inhibitor/mg protein		bovine	heart SMP-ATPase		affect	Positive	95% inhibition	170
Oligomycin	0.5 μg/ml		rat	liver SMP-ATPase		affect	Positive	75% inhibition	170
ossamycin	46 μg of inhibitor/mg protein		E. coli	pH gradient formation by membrane vesicle		affect	Positive	IC50	170
ossamycin	8 μM		human NCI-60 cell lines	F0F1-ATPase		affect	Positive	IC50	170
ossamycin	1.3 μg of inhibitor/mg protein		S. cerevisiae	SMP-ATPase		affect	Positive	IC50	170
venturicidin B						affect	Positive		170
Bedaquiline						affect	Positive		170
tributyltin chloride	200 nM		E. coli and	F0F1-ATPase		affect	Positive		170
tributyltin chloride	200 nM		I. tartaricus	F0F1-ATPase		affect	Positive		170
tributyltin chloride	1 μM		C. thermoaceticum	membrane-bound F0F1-ATPase		affect	Positive	47% inhibition	170
tributyltin chloride	5 μM		C. thermoaceticum	membrane-bound F0F1-ATPase		affect	Positive	87% inhibition	170
tributyltin chloride	1 μM			TF0F1-ATPase		affect	Positive	80% inhibition	170
NCCD	0.65 nmol/mg protein		bovine	heart SMP-ATPase		affect	Positive	IC50	170
NCCD	1 nmol NCCD/mg protein		bovine	heart SMP-ATPase		affect	Positive	85% inhibition	170
substrate analogs						affect	Positive		170
tentoxin	∼0.6 mol/mol		spinach	CF1-ATPase		affect	Positive	IC50	170
tentoxin	50 nM		spinach	CF1(-ɛ)-ATPase		affect	Positive	IC50	170
tentoxin	0.4-0.6 μM		lettuce	chloroplasts, photophosphorylation		affect	Positive	IC50	170
tentoxin	10 nM		spinach	CF1(-ɛ)-ATPase		affect	Positive	Ki	170
tentoxin	30-60 μM			TF1-ATPase		affect	Positive	Ki	170
tentoxin	8-10 nM		spinach	CF1(-ɛ)-ATPase		affect	Positive	Kd	170
efrapeptins						affect	Positive		170
azide						affect	Positive		170
resveratrol						affect	Positive		170
N,N'-dicyclohexylcarbodiimide	0.2 μg of inhibitor/mg protein		S. cerevisiae	SMP-ATPase		affect	Positive	IC50	170
N,N'-dicyclohexylcarbodiimide	1-5 μg of inhibitor/mg protein		T. pyriformis	SMP-ATPase		affect	Positive	IC50	170
N,N'-dicyclohexylcarbodiimide	200 μMa in less than 5 min and at ∼40 μMa in 30 min		R. rubrum	F1-ATPase		affect	Positive		170
N,N'-dicyclohexylcarbodiimide	1.9 μg/mg protein		C. fasciculata	SMP-ATPase		affect	Positive	IC50	170
N,N'-dicyclohexylcarbodiimide	1 mol DCCD/mol F1			EF1-ATPase		affect	Positive	95% inhibition	170
N,N'-dicyclohexylcarbodiimide	30 μM			membrane-bound EF0F1-ATPase		affect	Positive	maximal 70-80% inhibition	170
N,N'-dicyclohexylcarbodiimide	5 μM		C. thermoaceticum	membrane-bound F0F1-ATPase		affect	Positive	47% inhibition	170
N,N'-dicyclohexylcarbodiimide	2 mol inhibitor bound/mol F1		bovine	heart MF1-ATPase		affect	Positive	97% inhibition	170
N,N'-dicyclohexylcarbodiimide	1 mol inhibitor/mol F0		bovine	heart SMP-ATPase		affect	Positive	maximal inhibition	170
N,N'-dicyclohexylcarbodiimide	2 mol inhibitor/mol F0		bovine	heart H+-translocation		affect	Positive	maximal inhibition	170
N,N'-dicyclohexylcarbodiimide	1 mol inhibitor/mol F0		E. coli	membrane H+-translocation		affect	Positive	maximal inhibition	170
N,N'-dicyclohexylcarbodiimide						affect	Positive		170
woodward's reagent k						affect	Positive		170
woodward's reagent k						affect	Positive		170
cyclophilin D						affect	Positive		171
Rotenone	0.07 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
Rotenone	0.04 nmol/mg		bovine	mitochondria	NADH–O2	decrease	Positive	IC50	94
Deguelin	4.2 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	95
Piericidin A	0.06 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
Piericidin A	0.03 nmol/mg		bovine	mitochondria	NADH:O2	decrease	Positive	IC50	94
Ubicidin-3	0.17 nmol/mg		bovine	mitochondria	NADH:O2	decrease	Positive	IC50	96
Rolliniastatin-1	0.03 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	98
rolliniastatin-2	0.06 nmol/mg		bovine	mitochondria	NADH–Q-1	decrease	Positive	IC50	98
Otivarin	0.2 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	98
phenoxan	0.04 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
Thiangazole	0.04 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
myxalamid pi	15 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
phenalamid a2	0.6 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
Aurachin a	8.0 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
Myxothiazol	20 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	99
stigmatellin	100 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	99
TDS	40 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	99
aureothin	0.3 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
Cochlioquinone b	83 nmol/mg		bovine	mitochondria	NADH:O2	decrease	Positive	IC50	100
strobilurin a	>100 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	99
pterulone	36 μM		bovine	mitochondria	NADH:O2	decrease	Positive	IC50	101
Capsaicin	20–30 μM		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	102
Capsaicin	20–30 μM		bovine	mitochondria	NADH:O2	decrease	Positive	IC50	102
Rhein	30 μM		bovine	mitochondria	NADH:O2	decrease	Positive	IC50	104
Papaverine	5 μM		bovine	mitochondria	NADH–Q-1	decrease	Positive	IC50	30
Ubiquinone-2	2 μM		bovine	mitochondria	NADH–Q-1	decrease	Positive	IC50	106
Ubiquinone-3	40 μM		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	107
Idebenone	0.4 μM				NADH–Q	decrease	Positive	IC50	106
Pyridaben	2.4 nM				NADH–Q-1	decrease	Positive	IC50	108
Fenpyroximate	4.6 nM				NADH–Q-1	decrease	Positive	IC50	108
Fenpyroximate	18 nM				NADH–Q	decrease	Positive	IC50	103
Tebufenpyrad	6 nM				NADH–Q-1	decrease	Positive	IC50	108
fenazaquin	20 nM				NADH–Q-1	decrease	Positive	IC50	109
Benzimidazole	3 nM				NADH–Q	decrease	Positive	IC50	94
cyhalothrin	0.6 μM				NADH–DQ	decrease	Positive	IC50	110
6-chloro-benzothiadiazole	0.1 mM				NADH:O2	decrease	Positive	IC50	111
2M-TIO	40 μM				NADH–Q-1	decrease	Positive	IC50	112
amytal	0.2 mM				NADH–Q-1	decrease	Positive	IC50	112
meperidine	0.1 mM				NADH–Q-1	decrease	Positive	IC50	108
MPP+	0.3 mM				NADH:O2	decrease	Positive	IC50	114
MPP+	2–4 mM				NADH–Q	decrease	Positive	IC50	115
4'-decyl-mpp+	1.7 μM				NADH:O2	decrease	Positive	IC50	115
MQ18	0.2 μM				NADH–Q-1	decrease	Positive	IC50	116
2-methylharmine	0.18 mM				NADH:O2	decrease	Positive	IC50	117
TIQ	2 mM				NADH:O2	decrease	Positive	IC50	118
Haloperidol	3 μM				NADH–Q-1	decrease	Positive	IC50	119
HPP+	15 μM				NADH–Q-1	decrease	Positive	IC50	119
Dequalinium Chloride	11 μM				NADH:O2	decrease	Positive	IC50	120
Cinnarizine	5–10 μM				NADH–Q-1	decrease	Positive	IC50	121
para-nonylphenol	20 μM				NADH–Q	decrease	Positive	IC50	108
Catechol	0.4 mM				NADH–Q	decrease	Positive	IC50	108
CCCP	85 μM				NADH–Q-1	decrease	Positive	IC50	108
Erythrosin 5'-iodoacetamide	20 nM				NADH–O2	decrease	Positive	IC50	126
Safranine	17 μM				NADH–Q	decrease	Positive	IC50	127
dioc5(3)	1.5 μM				NADH–Q	decrease	Positive	IC50	127
dioc6(3)	80 nM				NADH–O2	decrease	Positive	IC50	126
Diphenyleneiodonium chloride	0.23 μM				NADH–Q-1c	decrease	Positive	IC50	128
N,N'-dicyclohexylcarbodiimide	0.1 mM				NADH–Q-1	decrease	Positive	IC50	129
o-phenanthroline	0.25 mM				NADH–Q	decrease	Positive	IC50	130
Leucinostatin	11 μg/mg protein		C. asciculate	SMP-ATPase		decrease	Positive	IC50	131
Leucinostatin	2 μg inhibitor/ml		spinach	chloroplast		decrease	Positive	IC50	132
Leucinostatin	0.1-0.4 μg/mg protein		rat	isolated liver mitochondria		decrease	Positive		133
efrapeptins	0.56 mol/mol F1		bovine	heart MF1-ATPase		decrease	Positive	IC50	134
efrapeptins	70 ng/ml		C. asciculate	MF1-ATPase		decrease	Positive	IC50	135
efrapeptins	0.3 μM		human	umbilical vein endothelial cell, nonmitochondrial ATP synthase		decrease	Positive	IC50	136
efrapeptins	0.5 μg/ml		R. rubrum	chromatophores		decrease	Positive	IC50	137
efrapeptins	0.05-0.5 μg of inhibitor/mg protein		T. pyriformis	SMP-ATPase		decrease	Positive	IC50	138
efrapeptins	21.5 μM			EF1-ATPase		decrease	Positive	ki	139
efrapeptins	10 nM		bovine	heart MF1-ATPase		decrease	Positive	kd	134
efrapeptins	2.4 mol inhibitor/mol enzyme		bovine	heart SMP-ATPase		decrease	Positive	complete inhibition	134
resveratrol	27.7 μM		rat	brain SMP, ATP synthesis		decrease	Positive		140
resveratrol	14 μM		rat	liver MF1-ATPase		decrease	Positive		141
resveratrol	19 μM		rat	brain M F0F1-ATPase		decrease	Positive		140
resveratrol	6.4 μM		bovine	bovine heart MF1-ATPase		decrease	Positive		142
resveratrol	2 μM		human	human umbilical vein endothelial cell, nonmitochondrial ATP synthase, ATP synthesis		decrease	Positive		136
Diethylstilbestrol	10 μM		rat	liver MF0F1-ATPase		decrease	Positive		143
Diethylstilbestrol	10-25 μM		rat	brain MF0F1-ATPase		decrease	Positive		141
SITS	∼1.3 μM		V. parahaemolyticus	F0F1-ATPase		decrease	Positive		144
SITS	25 μM		V. parahaemolyticus	F1-ATPase		decrease	Positive	95% inhibition	145
DIDS	20.9 μM		rat	liver MF1ATPase		decrease	Positive		146
quercetin	5 kmol/mol		bovine	heart MF1-ATPase		decrease	Positive	IC50	147
quercetin	85 μM		bovine	heart MF1-ATPase		decrease	Positive	IC50	148
quercetin	180 μM		bovine	heart SMP-ATPase		decrease	Positive	IC50	148
quercetin	50 μM		rat	brain F0F1-ATPase		decrease	Positive	IC50	140
quercetin	3 μM		rat	liver F1-ATPase		decrease	Positive	IC50	141
quercetin	2 kmol/mola		spinach	CF1-ATPase		decrease	Positive		147
quercetin	2.6 μg/mg protein		C. asciculate	SMP-ATPase		decrease	Positive	IC50	131
quercetin	0.2 mM		pig	heart MF1-ATPase		decrease	Positive	Ki	149
quercetin	27 μM		bovine	heart MF1-ATPase		decrease	Positive	Kd	147
quercetin	5 μM		C. thermoaceticum	membrane-bound F0F1-ATPase		decrease	Positive	46% inhibition	150
kaempferol	55 μM		rat	brain MF0F1-ATPase		decrease	Positive	IC50	140
morin	60 μM		rat	brain MF0F1-ATPase		decrease	Positive	IC50	140
apigenin	105 μM		rat	brain MF0F1-ATPase		decrease	Positive	IC50	140
genistein	55 μM		rat	brain MF0F1-ATPase		decrease	Positive	IC50	140
genistein	50 μM		rat	liver F1-ATPase		decrease	Positive	10% inhibition	141
Biochanin A	65 μM		rat	brain MF0F1-ATPase		decrease	Positive	IC50	140
Daidzein	127 μM		rat	brain MF0F1-ATPase		decrease	Positive	IC50	151
Oligomycin	152 μg inhibitor/mg protein		E. coli	membrane vesicle		decrease	Positive	IC50	152
Oligomycin	7.1 μg inhibitor/mg protein		C. asciculate	SMP-ATPase		decrease	Positive	IC50	131
Oligomycin	2.0-3.0 μg inhibitor/mg protein		S. cerevisiae	SMP-ATPase		decrease	Positive	IC50	153
Oligomycin	0.3 μM		human	NCI-60 cell lines, F0F1-ATPase		decrease	Positive	IC50	154
Oligomycin	15 ng inhibitor/mg protein		N. crassa	SMP-ATPase		decrease	Positive	Ki	155
Oligomycin	0.21 μM		bovine	heart MF0F1-ATPase		decrease	Positive	Ki	156
Oligomycin	0.4 μg inhibitor/mg protein		bovine	heart SMP-ATPase		decrease	Positive	95% inhibition	157
Oligomycin	0.5 μg/ml		rat	liver SMP-ATPase		decrease	Positive	75% inhibition	158
peliomycin	4.5 μg inhibitor/mg protein		S. cerevisiae	SMP-ATPase		decrease	Positive	IC50	153
venturicidin B	9 μg inhibitor/mg protein		E. coli	membrane vesicle		decrease	Positive	IC50	152
venturicidin B	11 μg inhibitor/mg protein		E. coli	membrane-bound ATPase		decrease	Positive	IC50	152
venturicidin B	0.13 μg inhibitor/mg protein					decrease	Positive	IC50	153
venturicidin B	0.06-0.18 (A and B) and 11.0 (X) μg inhibitor/mg protein		S. cerevisiae	SMP-ATPase		decrease	Positive	IC50	159
venturicidin B	5-11 μg inhibitor/mg protein		T. pyriformis			decrease	Positive	IC50	138
venturicidin B	3.0 μg/mg protein		C. asciculate	SMP-ATPase		decrease	Positive	IC50	131
venturicidin B	0.5 μM		spinach	thylakoids		decrease	Positive	IC50	160
venturicidin B	0.5 μM		spinach	thylakoids, ATPase		decrease	Positive	IC50	160
ossamycin	1.3 μg of inhibitor/mg protein		S. cerevisiae	SMP-ATPase		decrease	Positive	IC50	153
ossamycin	46 μg of inhibitor/mg protein		E. coli	membrane vesicle		decrease	Positive	IC50	152
ossamycin	8 μM		human	NCI-60 cell lines, F0F1-ATPase		decrease	Positive	IC50	154
apoptolidin	4-5 μM		S. cerevisiae	membrane-bound F0F1-ATPase		decrease	Positive	Ki	161
apoptolidin	18 μM		human	NCI-60 cell lines, F0F1-ATPase		decrease	Positive	IC50	154
cytovaricin	1 μM		human	NCI-60 cell lines, F0F1-ATPase		decrease	Positive	IC50	154
cytovaricin	0.4 μM		S. cerevisiae	membrane-bound F0F1-ATPase		decrease	Positive	Ki	161
ossamycin	0.8 μM			60 human cancer cell lines of the National Cancer Institute		decrease	Positive	mean	184
Perhexiline						affect	Positive		227
atpenin a5			bovine	heart mitochondria		affect	Positive		192
Carboxin			bovine	heart mitochondria		affect	Positive		192
Thenoyltrifluoroacetone			bovine	heart mitochondria		affect	Positive		192
HQNO			bovine	heart mitochondria		affect	Positive		192
Chlorpromazine						inhibit	Positive		197
Haloperidol						inhibit	Positive		197
Clozapine						inhibit	Positive		197
Nefazodone						inhibit	Positive		197
Metformin						inhibit	Positive		197
Phenformin						inhibit	Positive		197
Troglitazone						inhibit	Positive		197
Rosiglitazone						inhibit	Positive		197
Pioglitazone						inhibit	Positive		197
Oligomycin	8 nM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	IC50	3
aurovertin B	1.5 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	IC50	3
Amiodarone	50 μM		bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	p < 0.05	3
Amiodarone	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Amiodarone	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Amiodarone	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	decrease	Positive	p < 0.05	3
Amiodarone	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Chlorpromazine	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Chlorpromazine	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Chlorpromazine	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Diclofenac	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.01	3
gefitinib	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	decrease	Positive	p < 0.05	3
gefitinib	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Nefazodone	50 μM		bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	p < 0.001	3
Nefazodone	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.01	3
Nefazodone	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.01	3
Nefazodone	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	decrease	Positive	p < 0.001	3
Nefazodone	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
paroxetine	50 μM		bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	p < 0.01	3
paroxetine	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
paroxetine	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
paroxetine	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Simvastatin	50 μM		bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	p < 0.01	3
Simvastatin	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Simvastatin	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Simvastatin	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	decrease	Positive	p < 0.001	3
Simvastatin	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Tamoxifen	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Tamoxifen	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Tamoxifen	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	decrease	Positive	p < 0.001	3
Tamoxifen	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Tamoxifen	15 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	IC50	3
Tamoxifen	15 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	IC50	3
Tamoxifen	26.6 μM		bovine	heart mitochondria	Measurement of complex IV activity	decrease	Positive	IC50	3
Tamoxifen	8.1 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	IC50	3
Tamoxifen	4 μM		bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	IC50	3
Tamoxifen	1.6 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	IC50	3
Tamoxifen	30 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	IC50	3
Tamoxifen	30 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	IC50	3
Tamoxifen	29 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	IC50	3
Tamoxifen	26 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	IC50	3
Zidovudine						Interfere	Positive		307
Acyclovir						Interfere	Positive		307
Ganciclovir						Interfere	Positive		307
Zalcitabine						Interfere	Positive		307
tetracyclines						decrease	Positive		307
Ciprofloxacin						decrease	Positive		307
Clozapine						decrease	Positive		307
sertraline			rat	brain mitochondria		decrease	Positive		307
Fluoxetine			rat	brain mitochondria		decrease	Positive		307
sertraline			rat	liver mitochondria		decrease	Positive		307
Fluoxetine			rat	liver mitochondria		decrease	Positive		307
atorvastatin				C2C12 myoblasts		affect	Positive		180
Cerivastatin	100uM			C2C12 myoblasts	measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds	decrease	Positive		180
pitavastatin	100uM			C2C12 myoblasts	measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds	decrease	Positive		180
lovastatin	100uM			C2C12 myoblasts	measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds	decrease	Positive		180
Simvastatin	100uM			C2C12 myoblasts	Measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds. The lactone forms of the indicated statins were included in the assay medium at their cytotoxic EC50 concentration for measurement of their effect on the catalytic capacity.	decrease	Positive		180
Simvastatin	200uM		bovine	heart mitochondria	Reduction of the CIII cytochromes c1 and b was determined spectrophotometrically in bovine heart mitochondria.	affect	Positive	p < 0.01	180
Metformin	5 mM	24 hours	human	MCF7	Meassurement of mitochondrial respiration	decrease	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	human	MCF7	Meassurement of coupled respiration	decrease	Positive	p < 0.05	172
Metformin	5 mM	24 hours	human	MCF7	Meassurement of coupled respiration	decrease	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	mouse	NMuMG	Meassurement of mitochondrial respiration	decrease	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	mouse	NT2196	Meassurement of mitochondrial respiration	decrease	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	human	MCF10A	Meassurement of mitochondrial respiration	decrease	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	human	MCF7	Meassurement of mitochondrial respiration	decrease	Positive	p < 0.05	172
Metformin	66 mM		Bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	IC50	15
buformin	11.3 mM		Bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	IC50	15
Phenformin	1.2 mM		Bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	IC50	15

T001. NADH:ubiquinone reductase
T001060. quinone
T001061. semiquinone
T001062. quinol
T001063. flavin mononucleotide
T001064. iron-sulfur clusters
T002. Succinate dehydrogenase
T002007. Quinone pocket
T002008. Succinate pocket
T004. Quinol--cytochrome-c reductase
T004001. Cytochrome b
T004012. Qo site (Qp site or ubiquinol oxidation site)
T004013. Qi site (Qn site or quinone reduction site)
T005. Cytochrome c oxidase
T016. oxygen
T018. copper
T019. ATP synthase
T019002. Fo subunits
T019003. F1 subunits
T019004. ATP synthase subunit O, mitochondrial
T019011. ATP synthase subunit a
T408. Cytochrome c