GO:0045333 map00190
Function of mitochondria >> respiration

Related Drugs/Compounds

Compound	Dose	Time	Species	Model	Method	Action	Result	Positive criterion	Reference
Perhexiline	100 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	193
Perhexiline	200 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	193
Perhexiline	400 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	193
Perhexiline	100 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05	193
Perhexiline	200 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	193
Perhexiline	400 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	193
Perhexiline	200 μM	5 minutes preincubation	mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	193
erlotinib	17.4 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	increase	Positive	EC20	36
Fluconazole	186.6 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Pioglitazone						decrease	Positive		22
Pioglitazone						decrease	Positive		22
promethazine						increase	Positive		22
clomipramine						increase	Positive		22
clomipramine						decrease	Positive		22
imipramine						increase	Positive		22
Chlorpromazine						increase	Positive		22
Chlorpromazine						decrease	Positive		22
Chlorpromazine			rat	isolated liver mitochondria		decrease	Positive		23
Haloperidol			rat	isolated liver mitochondria		decrease	Positive		23
Risperidone			rat	isolated liver mitochondria		decrease	Positive		23
quetiapine			rat	isolated liver mitochondria		decrease	Positive		23
Antimycin A						decrease	Positive		26
Myxothiazol			bovine	heart mitochondria		decrease	Positive		29
Papaverine						decrease	Positive		30
Lamivudine	317.4 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Thenoyltrifluoroacetone						decrease	Positive		33
Acetaminophen						decrease	Positive		35
Acetaminophen						decrease	Positive		35
Lidocaine	188.2 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	increase	Positive	EC20	36
Acetylsalicylic acid						decrease	Positive		35
Acetylsalicylic acid						decrease	Positive		35
Flutamide						decrease	Positive		35
Ketoconazole						decrease	Positive		35
mefloquine						decrease	Positive		35
lovastatin	6.2 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Metformin						decrease	Positive		35
Nefazodone						decrease	Positive		35
lumiracoxib	12 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Nitrofurantoin						decrease	Positive		35
Paraquat						decrease	Positive		35
paroxetine						decrease	Positive		35
paroxetine						decrease	Positive		35
paroxetine						decrease	Positive		35
paroxetine						decrease	Positive		35
Manganese	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Phenformin						decrease	Positive		35
Pioglitazone						decrease	Positive		35
Pioglitazone						decrease	Positive		35
promethazine						decrease	Positive		35
Rosiglitazone						decrease	Positive		35
Rotenone						decrease	Positive		35
Tamoxifen						decrease	Positive		35
Tamoxifen						decrease	Positive		35
Tamoxifen						decrease	Positive		35
Tamoxifen						decrease	Positive		35
Metformin	351.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Simvastatin	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Troglitazone						decrease	Positive		35
Antimycin A						decrease	Positive		35
Myxothiazol						decrease	Positive		35
Oligomycin						decrease	Positive		35
Nicotine	312 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Thenoyltrifluoroacetone						decrease	Positive		35
alpidem						decrease	Positive		36
nifuroxazide	3.7 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Amiodarone						decrease	Positive		36
benzbromarone						decrease	Positive		37
Chlorpromazine						decrease	Positive		7
clomipramine						decrease	Positive		38
Diclofenac						decrease	Positive		39
Flutamide						decrease	Positive		41
Nitrofurantoin	8.7 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Ketoconazole						decrease	Positive		36
lovastatin						decrease	Positive		36
Perhexiline	87.7 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Phenformin						decrease	Positive		43
Rosiglitazone						decrease	Positive		7
Simvastatin						decrease	Positive		7
Piroxicam	6.6 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
sitaxsentan						decrease	Positive		44
Tamoxifen						decrease	Positive		46
Troglitazone						decrease	Positive		7
Doxorubicin						decrease	Positive		36
propylparaben	28.4 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
imipramine						decrease	Positive		36
sertraline						decrease	Positive		48
zoniporide						decrease	Positive		50
Pyrazinamide	190.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
pentamidine						decrease	Positive		51
ritonavir						decrease	Positive		36
Tenofovir						decrease	Positive		52
Polymyxin B			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
beclomethasone			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
bicalutamide			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
danazol			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
ethynodiol diacetate			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
riboflavin	182.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
retinoic acid			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
aripiprazole			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
axitinib			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
clofilium			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
tenidap			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
darifenacin			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
pimozide			rat	isolated liver mitochondria	measurements of mitochondrial respiration; RST inhibition assay, RST uncoupling assay; IC 50ratio of glucose/galactose assay	decrease	Positive		53
Tamoxifen	15 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	IC50	3
Gemfibrozil				isolated mitochondria		decrease	Positive		7
Amitriptyline			pig	brain mitochondria		decrease	Positive		60
Bupivacaine						decrease	Positive		61
citalopram			pig	brain mitochondria		decrease	Positive		62
citalopram			pig	brain mitochondria		decrease	Positive		62
citalopram			pig	brain mitochondria		decrease	Positive		62
Haloperidol						decrease	Positive		23
propranolol			pig	brain mitochondria		decrease	Positive		60
Indomethacin			rat	isolated liver mitochondria		decrease	Positive		65
ochratoxin a			rat	isolated liver mitochondria		decrease	Positive		66
tacrolimus			rat	isolated kidney mitochondria		decrease	Positive		68
Troglitazone	6 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Piericidin A						affect	Positive		53
rolliniastatin-2						affect	Positive		53
Idebenone						affect	Positive		53
Rotenone						affect	Positive		53
piericidin a						affect	Positive		53
piericidin b						affect	Positive		53
aureothin						affect	Positive		53
amytal						affect	Positive		53
4-alkyl-acridones						affect	Positive		53
4′-alkyl-mpp+ analoguesc						affect	Positive		53
phenoxan						affect	Positive		53
quinol products						affect	Positive		53
reduced q-2b						affect	Positive		53
Myxothiazol						affect	Positive		53
stigmatellin						affect	Positive		53
TDS						affect	Positive		53
2M-TIO						affect	Positive		53
meperidine						affect	Positive		53
para-nonylphenol						affect	Positive		53
Diphenyleneiodonium chloride						affect	Positive		69
ethoxyformic anhydride						affect	Positive		70
ethoxyformic anhydride						decrease	Positive		70
ethoxyformic anhydride						decrease	Positive		70
flutolanil						affect	Positive		71
atpenin a5						affect	Positive		71
Carboxin						affect	Positive		71
penthiopyrad						affect	Positive		71
boscalid						affect	Positive		71
fluopyram						affect	Positive		71
dinitrophenol-17						affect	Positive		71
atpenin a5						affect	Positive		72
thiophene carboxamides						affect	Positive		73
HQNO						affect	Positive		74
Polymyxin B	1.6 μg/ml		Mycobacterium smegmatis	membrane-bound dehydrogenases		decrease	Positive	IC50	76
nanaomycin a	31 μg/ml		Mycobacterium smegmatis	membrane-bound dehydrogenases		decrease	Positive	IC50	76
siccanin			P. aeruginosa	PAO1 cells		affect	Positive		76
cyenopyrafen						affect	Positive		77
pyflubumide						affect	Positive		77
3-Nitropropionate						affect	Positive		78
Malonate						affect	Positive		79
british anti-lewisite						affect	Positive		80
Myxothiazol						affect	Positive		81
moas						affect	Positive		82
azoxystrobin						affect	Positive		83
oudemansin a						affect	Positive		84
strobilurin a						affect	Positive		84
cpmb-oxime						affect	Positive		84
azoxystrobin	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect	Positive		83
famoxadone	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect	Positive		83
stigmatellin	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect	Positive		83
uhdbt	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect	Positive		83
hhdbt uhnq	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect	Positive		83
dibromothymoquinone	100 mM	incubated overnight	bovine	isolated heart mitochondria	Measurements of redox potentials of the ISP	affect	Positive		83
Antimycin A			bovine	isolated heart mitochondria cytochrome bc1 complex		affect	Positive		166
diuron						affect	Positive		83
NQNO			bovine	isolated heart mitochondria cytochrome bc1 complex		affect	Positive		166
NQNO			bovine	isolated heart mitochondria cytochrome bc1 complex		affect	Positive		166
Carbon Monoxide						affect	Positive		167
nitric oxide						affect	Positive		167
Cyanide						affect	Positive		167
azides						affect	Positive		167
sulfide						affect	Positive		167
formate						affect	Positive		167
ethylxanthate						affect	Positive		167
bisulfate						affect	Positive		167
semicarbazide						affect	Positive		167
salicyaldoxime						affect	Positive		167
ethylxanthate						decrease	Positive		167
bisulfate						decrease	Positive		167
semicarbazide						decrease	Positive		167
salicyaldoxime						decrease	Positive		167
adda 5			human	U251 mitochondria	CcO activity assay	affect	Positive		168
tetrathiomolybdate	30 μM	48 hour	human	ECC-1		affect	Positive		169
tetrathiomolybdate	30 μM	48 hour	human	IGROV-1		affect	Positive		169
Oligomycin	152 μg inhibitor/mg protein		E. coli	membrane vesicle, pH gradient formation		affect	Positive		170
Oligomycin	7.1 μg inhibitor/mg protein		C. asciculate	SMP-ATPase		affect	Positive	IC50	170
Oligomycin	2.0-3.0 μg inhibitor/mg protein		S. cerevisiae	SMP-ATPase		affect	Positive	IC50	170
Oligomycin	0.3 μM		human NCI-60 cell lines	F0F1-ATPase		affect	Positive	IC50	170
Oligomycin	15 ng inhibitor/mg protein		N. crassa	SMP-ATPase		affect	Positive	Ki	170
Oligomycin	0.21 μM		bovine	heart MF0F1-ATPase		affect	Positive	Ki	170
Oligomycin	0.4 μg inhibitor/mg protein		bovine	heart SMP-ATPase		affect	Positive	95% inhibition	170
Oligomycin	0.5 μg/ml		rat	liver SMP-ATPase		affect	Positive	75% inhibition	170
ossamycin	46 μg of inhibitor/mg protein		E. coli	pH gradient formation by membrane vesicle		affect	Positive	IC50	170
ossamycin	8 μM		human NCI-60 cell lines	F0F1-ATPase		affect	Positive	IC50	170
ossamycin	1.3 μg of inhibitor/mg protein		S. cerevisiae	SMP-ATPase		affect	Positive	IC50	170
venturicidin B						affect	Positive		170
Bedaquiline						affect	Positive		170
tributyltin chloride	200 nM		E. coli and	F0F1-ATPase		affect	Positive		170
tributyltin chloride	200 nM		I. tartaricus	F0F1-ATPase		affect	Positive		170
tributyltin chloride	1 μM		C. thermoaceticum	membrane-bound F0F1-ATPase		affect	Positive	47% inhibition	170
tributyltin chloride	5 μM		C. thermoaceticum	membrane-bound F0F1-ATPase		affect	Positive	87% inhibition	170
tributyltin chloride	1 μM			TF0F1-ATPase		affect	Positive	80% inhibition	170
NCCD	0.65 nmol/mg protein		bovine	heart SMP-ATPase		affect	Positive	IC50	170
NCCD	1 nmol NCCD/mg protein		bovine	heart SMP-ATPase		affect	Positive	85% inhibition	170
substrate analogs						affect	Positive		170
tentoxin	∼0.6 mol/mol		spinach	CF1-ATPase		affect	Positive	IC50	170
tentoxin	50 nM		spinach	CF1(-ɛ)-ATPase		affect	Positive	IC50	170
tentoxin	0.4-0.6 μM		lettuce	chloroplasts, photophosphorylation		affect	Positive	IC50	170
tentoxin	10 nM		spinach	CF1(-ɛ)-ATPase		affect	Positive	Ki	170
tentoxin	30-60 μM			TF1-ATPase		affect	Positive	Ki	170
tentoxin	8-10 nM		spinach	CF1(-ɛ)-ATPase		affect	Positive	Kd	170
efrapeptins						affect	Positive		170
azide						affect	Positive		170
resveratrol						affect	Positive		170
N,N'-dicyclohexylcarbodiimide	0.2 μg of inhibitor/mg protein		S. cerevisiae	SMP-ATPase		affect	Positive	IC50	170
N,N'-dicyclohexylcarbodiimide	1-5 μg of inhibitor/mg protein		T. pyriformis	SMP-ATPase		affect	Positive	IC50	170
N,N'-dicyclohexylcarbodiimide	200 μMa in less than 5 min and at ∼40 μMa in 30 min		R. rubrum	F1-ATPase		affect	Positive		170
N,N'-dicyclohexylcarbodiimide	1.9 μg/mg protein		C. fasciculata	SMP-ATPase		affect	Positive	IC50	170
N,N'-dicyclohexylcarbodiimide	1 mol DCCD/mol F1			EF1-ATPase		affect	Positive	95% inhibition	170
N,N'-dicyclohexylcarbodiimide	30 μM			membrane-bound EF0F1-ATPase		affect	Positive	maximal 70-80% inhibition	170
N,N'-dicyclohexylcarbodiimide	5 μM		C. thermoaceticum	membrane-bound F0F1-ATPase		affect	Positive	47% inhibition	170
N,N'-dicyclohexylcarbodiimide	2 mol inhibitor bound/mol F1		bovine	heart MF1-ATPase		affect	Positive	97% inhibition	170
N,N'-dicyclohexylcarbodiimide	1 mol inhibitor/mol F0		bovine	heart SMP-ATPase		affect	Positive	maximal inhibition	170
N,N'-dicyclohexylcarbodiimide	2 mol inhibitor/mol F0		bovine	heart H+-translocation		affect	Positive	maximal inhibition	170
N,N'-dicyclohexylcarbodiimide	1 mol inhibitor/mol F0		E. coli	membrane H+-translocation		affect	Positive	maximal inhibition	170
N,N'-dicyclohexylcarbodiimide						affect	Positive		170
woodward's reagent k						affect	Positive		170
woodward's reagent k						affect	Positive		170
cyclophilin D						affect	Positive		171
triclosan	0.5 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		85
triclosan	0.5 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		85
triclosan	0.5 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		85
Benzo(A)Pyrene	100 µg/l		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		85
Benzo(A)Pyrene	1000 µg/l		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		85
phenanthrene	500 µg/l		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		85
phenanthrene	100 µg/l		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		85
phenanthrene	500 µg/l		zebrafish		XFe24 Extracellular Flux Analyzer	increase	Positive		85
fluoranthene	100 µg/l		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		85
fluoranthene	100 µg/l		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		85
fluoranthene	100 µg/l		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		85
fluoranthene	100 µg/l		zebrafish		XFe24 Extracellular Flux Analyzer	increase	Positive		85
Phenanthrenequinone	2 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		86
benz(a)anthracene-7,12-dione	5 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		86
9,10-anthraquinone	20 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		86
1,9-benz-10-anthrone	10 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		86
Phenanthrenequinone	2 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		86
xanthone	20 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		86
benz(a)anthracene-7,12-dione	5 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		86
1,9-benz-10-anthrone	10 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		86
9,10-anthraquinone	20 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		86
1,9-benz-10-anthrone	10 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		86
xanthone	20 µM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		86
triclosan	30 μM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		89
triclosan	30 μM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		89
triclosan	30 μM		zebrafish		XFe24 Extracellular Flux Analyzer	increase	Positive		89
2,4-dinitrophenol	0.5 μM / 6 hpf		zebrafish		XFe24 Extracellular Flux Analyzer	increase	Positive		90
2,4-dinitrophenol	0.5 μM / 48 hpf		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		90
2,4-dinitrophenol	0.5 μM / 24 hpf		zebrafish		XFe24 Extracellular Flux Analyzer	affect	Positive		90
2,4-dinitrophenol	0.5 μM / 48 hpf		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		90
2,4-dinitrophenol	0.5 μM / 24 hpf		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		90
2,4-dinitrophenol	0.5 μM / 24 hpf		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		90
2,4-dinitrophenol	0.5 μM / 24 hpf		zebrafish		XFe24 Extracellular Flux Analyzer	increase	Positive		90
quercetin	1 µg/l		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		91
quercetin	1 µg/l		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		91
quercetin	10 µg/l		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		91
diquat	100 μM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		92
diquat	100 μM		zebrafish		XFe24 Extracellular Flux Analyzer	decrease	Positive		92
Rotenone	0.07 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
Rotenone	0.04 nmol/mg		bovine	mitochondria	NADH–O2	decrease	Positive	IC50	94
Deguelin	4.2 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	95
Piericidin A	0.06 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
Piericidin A	0.03 nmol/mg		bovine	mitochondria	NADH:O2	decrease	Positive	IC50	94
Ubicidin-3	0.17 nmol/mg		bovine	mitochondria	NADH:O2	decrease	Positive	IC50	96
Rolliniastatin-1	0.03 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	98
rolliniastatin-2	0.06 nmol/mg		bovine	mitochondria	NADH–Q-1	decrease	Positive	IC50	98
Otivarin	0.2 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	98
phenoxan	0.04 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
Thiangazole	0.04 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
myxalamid pi	15 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
phenalamid a2	0.6 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
Aurachin a	8.0 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
Myxothiazol	20 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	99
stigmatellin	100 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	99
TDS	40 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	99
aureothin	0.3 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	94
Cochlioquinone b	83 nmol/mg		bovine	mitochondria	NADH:O2	decrease	Positive	IC50	100
strobilurin a	>100 nmol/mg		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	99
pterulone	36 μM		bovine	mitochondria	NADH:O2	decrease	Positive	IC50	101
Capsaicin	20–30 μM		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	102
Capsaicin	20–30 μM		bovine	mitochondria	NADH:O2	decrease	Positive	IC50	102
Rhein	30 μM		bovine	mitochondria	NADH:O2	decrease	Positive	IC50	104
Papaverine	5 μM		bovine	mitochondria	NADH–Q-1	decrease	Positive	IC50	30
Ubiquinone-2	2 μM		bovine	mitochondria	NADH–Q-1	decrease	Positive	IC50	106
Ubiquinone-3	40 μM		bovine	mitochondria	NADH–Q	decrease	Positive	IC50	107
Idebenone	0.4 μM				NADH–Q	decrease	Positive	IC50	106
Pyridaben	2.4 nM				NADH–Q-1	decrease	Positive	IC50	108
Fenpyroximate	4.6 nM				NADH–Q-1	decrease	Positive	IC50	108
Fenpyroximate	18 nM				NADH–Q	decrease	Positive	IC50	103
Tebufenpyrad	6 nM				NADH–Q-1	decrease	Positive	IC50	108
fenazaquin	20 nM				NADH–Q-1	decrease	Positive	IC50	109
Benzimidazole	3 nM				NADH–Q	decrease	Positive	IC50	94
cyhalothrin	0.6 μM				NADH–DQ	decrease	Positive	IC50	110
6-chloro-benzothiadiazole	0.1 mM				NADH:O2	decrease	Positive	IC50	111
2M-TIO	40 μM				NADH–Q-1	decrease	Positive	IC50	112
amytal	0.2 mM				NADH–Q-1	decrease	Positive	IC50	112
meperidine	0.1 mM				NADH–Q-1	decrease	Positive	IC50	108
MPP+	0.3 mM				NADH:O2	decrease	Positive	IC50	114
MPP+	2–4 mM				NADH–Q	decrease	Positive	IC50	115
Rosiglitazone	1uM	24 and 48 hours	Murine	3T3-L1 adipocytes differentiated	96-well BD Oxygen Biosensor System plates	increase	Positive		179
4'-decyl-mpp+	1.7 μM				NADH:O2	decrease	Positive	IC50	115
MQ18	0.2 μM				NADH–Q-1	decrease	Positive	IC50	116
2-methylharmine	0.18 mM				NADH:O2	decrease	Positive	IC50	117
TIQ	2 mM				NADH:O2	decrease	Positive	IC50	118
Haloperidol	3 μM				NADH–Q-1	decrease	Positive	IC50	119
HPP+	15 μM				NADH–Q-1	decrease	Positive	IC50	119
Dequalinium Chloride	11 μM				NADH:O2	decrease	Positive	IC50	120
Cinnarizine	5–10 μM				NADH–Q-1	decrease	Positive	IC50	121
para-nonylphenol	20 μM				NADH–Q	decrease	Positive	IC50	108
Catechol	0.4 mM				NADH–Q	decrease	Positive	IC50	108
CCCP	85 μM				NADH–Q-1	decrease	Positive	IC50	108
Erythrosin 5'-iodoacetamide	20 nM				NADH–O2	decrease	Positive	IC50	126
Safranine	17 μM				NADH–Q	decrease	Positive	IC50	127
dioc5(3)	1.5 μM				NADH–Q	decrease	Positive	IC50	127
dioc6(3)	80 nM				NADH–O2	decrease	Positive	IC50	126
Diphenyleneiodonium chloride	0.23 μM				NADH–Q-1c	decrease	Positive	IC50	128
N,N'-dicyclohexylcarbodiimide	0.1 mM				NADH–Q-1	decrease	Positive	IC50	129
o-phenanthroline	0.25 mM				NADH–Q	decrease	Positive	IC50	130
Leucinostatin	11 μg/mg protein		C. asciculate	SMP-ATPase		decrease	Positive	IC50	131
Leucinostatin	2 μg inhibitor/ml		spinach	chloroplast		decrease	Positive	IC50	132
Leucinostatin	0.1-0.4 μg/mg protein		rat	isolated liver mitochondria		decrease	Positive		133
efrapeptins	0.56 mol/mol F1		bovine	heart MF1-ATPase		decrease	Positive	IC50	134
efrapeptins	70 ng/ml		C. asciculate	MF1-ATPase		decrease	Positive	IC50	135
efrapeptins	0.3 μM		human	umbilical vein endothelial cell, nonmitochondrial ATP synthase		decrease	Positive	IC50	136
efrapeptins	0.5 μg/ml		R. rubrum	chromatophores		decrease	Positive	IC50	137
efrapeptins	0.05-0.5 μg of inhibitor/mg protein		T. pyriformis	SMP-ATPase		decrease	Positive	IC50	138
efrapeptins	21.5 μM			EF1-ATPase		decrease	Positive	ki	139
efrapeptins	10 nM		bovine	heart MF1-ATPase		decrease	Positive	kd	134
efrapeptins	2.4 mol inhibitor/mol enzyme		bovine	heart SMP-ATPase		decrease	Positive	complete inhibition	134
resveratrol	27.7 μM		rat	brain SMP, ATP synthesis		decrease	Positive		140
resveratrol	14 μM		rat	liver MF1-ATPase		decrease	Positive		141
resveratrol	19 μM		rat	brain M F0F1-ATPase		decrease	Positive		140
resveratrol	6.4 μM		bovine	bovine heart MF1-ATPase		decrease	Positive		142
resveratrol	2 μM		human	human umbilical vein endothelial cell, nonmitochondrial ATP synthase, ATP synthesis		decrease	Positive		136
Diethylstilbestrol	10 μM		rat	liver MF0F1-ATPase		decrease	Positive		143
Diethylstilbestrol	10-25 μM		rat	brain MF0F1-ATPase		decrease	Positive		141
SITS	∼1.3 μM		V. parahaemolyticus	F0F1-ATPase		decrease	Positive		144
SITS	25 μM		V. parahaemolyticus	F1-ATPase		decrease	Positive	95% inhibition	145
DIDS	20.9 μM		rat	liver MF1ATPase		decrease	Positive		146
quercetin	5 kmol/mol		bovine	heart MF1-ATPase		decrease	Positive	IC50	147
quercetin	85 μM		bovine	heart MF1-ATPase		decrease	Positive	IC50	148
quercetin	180 μM		bovine	heart SMP-ATPase		decrease	Positive	IC50	148
quercetin	50 μM		rat	brain F0F1-ATPase		decrease	Positive	IC50	140
quercetin	3 μM		rat	liver F1-ATPase		decrease	Positive	IC50	141
quercetin	2 kmol/mola		spinach	CF1-ATPase		decrease	Positive		147
quercetin	2.6 μg/mg protein		C. asciculate	SMP-ATPase		decrease	Positive	IC50	131
quercetin	0.2 mM		pig	heart MF1-ATPase		decrease	Positive	Ki	149
quercetin	27 μM		bovine	heart MF1-ATPase		decrease	Positive	Kd	147
quercetin	5 μM		C. thermoaceticum	membrane-bound F0F1-ATPase		decrease	Positive	46% inhibition	150
kaempferol	55 μM		rat	brain MF0F1-ATPase		decrease	Positive	IC50	140
morin	60 μM		rat	brain MF0F1-ATPase		decrease	Positive	IC50	140
apigenin	105 μM		rat	brain MF0F1-ATPase		decrease	Positive	IC50	140
genistein	55 μM		rat	brain MF0F1-ATPase		decrease	Positive	IC50	140
genistein	50 μM		rat	liver F1-ATPase		decrease	Positive	10% inhibition	141
Biochanin A	65 μM		rat	brain MF0F1-ATPase		decrease	Positive	IC50	140
Daidzein	127 μM		rat	brain MF0F1-ATPase		decrease	Positive	IC50	151
Oligomycin	152 μg inhibitor/mg protein		E. coli	membrane vesicle		decrease	Positive	IC50	152
Oligomycin	7.1 μg inhibitor/mg protein		C. asciculate	SMP-ATPase		decrease	Positive	IC50	131
Oligomycin	2.0-3.0 μg inhibitor/mg protein		S. cerevisiae	SMP-ATPase		decrease	Positive	IC50	153
Oligomycin	0.3 μM		human	NCI-60 cell lines, F0F1-ATPase		decrease	Positive	IC50	154
Oligomycin	15 ng inhibitor/mg protein		N. crassa	SMP-ATPase		decrease	Positive	Ki	155
Oligomycin	0.21 μM		bovine	heart MF0F1-ATPase		decrease	Positive	Ki	156
Oligomycin	0.4 μg inhibitor/mg protein		bovine	heart SMP-ATPase		decrease	Positive	95% inhibition	157
Oligomycin	0.5 μg/ml		rat	liver SMP-ATPase		decrease	Positive	75% inhibition	158
peliomycin	4.5 μg inhibitor/mg protein		S. cerevisiae	SMP-ATPase		decrease	Positive	IC50	153
venturicidin B	9 μg inhibitor/mg protein		E. coli	membrane vesicle		decrease	Positive	IC50	152
venturicidin B	11 μg inhibitor/mg protein		E. coli	membrane-bound ATPase		decrease	Positive	IC50	152
venturicidin B	0.13 μg inhibitor/mg protein					decrease	Positive	IC50	153
venturicidin B	0.06-0.18 (A and B) and 11.0 (X) μg inhibitor/mg protein		S. cerevisiae	SMP-ATPase		decrease	Positive	IC50	159
venturicidin B	5-11 μg inhibitor/mg protein		T. pyriformis			decrease	Positive	IC50	138
venturicidin B	3.0 μg/mg protein		C. asciculate	SMP-ATPase		decrease	Positive	IC50	131
venturicidin B	0.5 μM		spinach	thylakoids		decrease	Positive	IC50	160
venturicidin B	0.5 μM		spinach	thylakoids, ATPase		decrease	Positive	IC50	160
ossamycin	1.3 μg of inhibitor/mg protein		S. cerevisiae	SMP-ATPase		decrease	Positive	IC50	153
ossamycin	46 μg of inhibitor/mg protein		E. coli	membrane vesicle		decrease	Positive	IC50	152
ossamycin	8 μM		human	NCI-60 cell lines, F0F1-ATPase		decrease	Positive	IC50	154
apoptolidin	4-5 μM		S. cerevisiae	membrane-bound F0F1-ATPase		decrease	Positive	Ki	161
apoptolidin	18 μM		human	NCI-60 cell lines, F0F1-ATPase		decrease	Positive	IC50	154
cytovaricin	1 μM		human	NCI-60 cell lines, F0F1-ATPase		decrease	Positive	IC50	154
cytovaricin	0.4 μM		S. cerevisiae	membrane-bound F0F1-ATPase		decrease	Positive	Ki	161
ossamycin	0.8 μM			60 human cancer cell lines of the National Cancer Institute		decrease	Positive	mean	184
Simvastatin	50 μM		bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	p < 0.01	3
Perhexiline						affect	Positive		227
benzarone	20 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzarone	50 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
atpenin a5			bovine	heart mitochondria		affect	Positive		192
Carboxin			bovine	heart mitochondria		affect	Positive		192
Thenoyltrifluoroacetone			bovine	heart mitochondria		affect	Positive		192
HQNO			bovine	heart mitochondria		affect	Positive		192
benzbromarone	0.1 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Nimesulide							Positive		197
Cephaloglycin						inhibit	Positive		197
Imipenem						inhibit	Positive		197
Chlorpromazine						inhibit	Positive		197
Haloperidol						inhibit	Positive		197
Clozapine						inhibit	Positive		197
Nefazodone						inhibit	Positive		197
Metformin						inhibit	Positive		197
Phenformin						inhibit	Positive		197
Troglitazone						inhibit	Positive		197
Rosiglitazone						inhibit	Positive		197
Pioglitazone						inhibit	Positive		197
Efavirenz							Positive		197
Barbiturate						decrease	Positive		197
Phenformin	100 nmol/mg mitochondrial protein		rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
Rotenone	10–100 nmol			SK-N-MC Neuroblastoma cells		decrease	Positive		242
Lead	1%,2%,4% in oral chow		Wistar rats				Positive		242
buformin	100 nmol/mg mitochondrial protein	40 min preincubation	rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
Cisplatin						decrease	Positive		307
Cyclophosphamide						decrease	Positive		307
2‐Butylbenzofuran	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Lonidamine							Positive		249
Yohimbine			mouse	neuron	Oxygen consumption rate (OCR) or extracellular acidification rate (ECAR) measurements from permeabilized neurons and isolated brain mitochondria were performed using the XF96 Extracellular Flux analyzer (Seahorse Bioscience).	increase	Positive		269
Dyclonine			mouse	neuron	Oxygen consumption rate (OCR) or extracellular acidification rate (ECAR) measurements from permeabilized neurons and isolated brain mitochondria were performed using the XF96 Extracellular Flux analyzer (Seahorse Bioscience).	increase	Positive		269
2‐Butylbenzofuran	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Perhexiline	100 μM		mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	increase	Positive	p < 0.01	193
Perhexiline	200 μM		mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	increase	Positive	p < 0.01	193
tacrolimus	50 µg/ml	12hr		INS-1 cells	XF24 Extracellular Flux Analyzer	decrease	Positive		322
tacrolimus	50 µg/ml	12hr		INS-1 cells	XF24 Extracellular Flux Analyzer	decrease	Positive		322
tacrolimus	50 µg/ml	12hr		INS-1 cells	XF24 Extracellular Flux Analyzer	decrease	Positive		322
tacrolimus	50 µg/ml	12hr		INS-1 cells	XF24 Extracellular Flux Analyzer	decrease	Positive		322
tacrolimus	1 μM		rat	isolated kidney mitochondria	Oxygen consumption was measured with a Clark‐type electrode	decrease	Positive	10%	323
rapamycin	1 μM		rat	isolated kidney mitochondria	Oxygen consumption was measured with a Clark‐type electrode	decrease	Positive	11%	323
tacrolimus	3.4E−11 M and 2.3E−8 M		rat	isolated kidney mitochondria	Oxygen consumption was measured with a Clark‐type electrode	decrease	Positive	EC50 ; maximal inhibitory effect was about 20%	323
rapamycin	4.4×10−10 M		rat	isolated kidney mitochondria	Oxygen consumption was measured with a Clark‐type electrode	decrease	Positive	EC50 ; maximal inhibitory effect was about14%	323
tacrolimus	1 μM		rat	isolated kidney mitochondria	Oxygen consumption was measured with a Clark‐type electrode	decrease	Positive		323
rapamycin	1 μM		rat	isolated kidney mitochondria	Oxygen consumption was measured with a Clark‐type electrode	decrease	Positive		323
MG-132	20 μM	6 hr		HeLa cells	Mitochondrial respiration was calculated by measuring oxygen consumption rate (OCR) and proton flux under a series of conditions using a Seahorse Flux analyzer.	inhibit	Positive		291
Diazepam	70 μg/ml			pig kidney embryo cells	polarographic cell (1.2 ml)	inhibit	Positive		293
Cadmium	50-500 μM	3hr	rat	PC12 cells	Cell respiration was determined polarographically with the help of Clark oxygen electrode	decrease	Positive		300
Mercury	10-50 μM	3hr	rat	PC12 cells	Cell respiration was determined polarographically with the help of Clark oxygen electrode	decrease	Positive		300
Copper	50 μM		rat	PC12 cells	Cell respiration was determined polarographically with the help of Clark oxygen electrode	decrease	Positive		300
Ketoconazole	I50=32, 74, 65, 75, 500μM for substrates Glutamate/Malate, Pyruvate/Malate, Ornithine/Malate, Arginine/Malate and Succinate repectively		rat	liver mitochondria	Clark electrode	inhibit	Positive		303
Miconazole	I50=100, 160, 160, 170, 150 μM for substrates Glutamate/Malate, Pyruvate/Malate, Ornithine/Malate, Arginine/Malate and Succinate repectively		rat	liver mitochondria	Clark electrode	inhibit	Positive		303
Amiodarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Gentamicin	5mM	10min	rat	isolated rat liver (and kidney) mitochondria	Oroboros O2K Oxygraph, complex II-based state 4 respiration	increase	Positive		316
Gentamicin	5mM	10min	rat	isolated rat liver (and kidney) mitochondria	Oroboros O2K Oxygraph, complex II-based state 3u respiration	decrease	Positive		316
Gentamicin	5mM	10min	rat	isolated rat liver mitochondria	Oroboros O2K Oxygraph, complex I-based state 4 respiration	increase	Positive		316
Gentamicin	5mM	10min	rat	isolated rat liver mitochondria	Oroboros O2K Oxygraph, complex I-based state 3u respiration	decrease	Positive		316
Gentamicin	5mM	10min	rat	isolated rat liver (and kidney) mitochondria	Oroboros O2K Oxygraph	reduce	Positive		316
Berberine	1-10 µM			isolated rat muscle mitochondria	Clark type oxygen electrode (Strathkelvin Instruments)	decrease	Positive		328
Acetaminophen	348.5 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Acetylsalicylic acid	> 800 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
alpidem	25.6 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Amantadine	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Ambroxol	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Amiodarone	45.92 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Amoxicillin	90.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	increase	Positive	EC20	36
Ampicillin	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Antipyrine	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Arsenic trioxide	< 50 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Biotin	44.5 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
lumiracoxib	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
bisacodyl	50.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
estradiol acetate	> 200 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Bupivacaine	60.6 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Busulfan	169.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Butein	29.6 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Caffeine	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Capsaicin	15 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Carbamazepine	53.4 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Cefixime	41.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Chlorambucil	138.7 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Ciprofloxacin	195.0 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	increase	Positive	EC20	36
Clodronate	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Clotrimazole	2.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
curcumin	> 200 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Daunorubicin	12.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
dexamethasone valerate	> 200 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Diazoxide	4.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Diclofenac	9.1 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Diflunisal	9.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Doxorubicin	15.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
erlotinib	328.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Fluconazole	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Flufenamic Acid	1.7 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
gefitinib	269.6 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
genistein	81.3 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Glimepiride	16.6 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Gossypol	30.3 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Ibuprofen	170.1 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
imipramine	75.5 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	increase	Positive	EC20	36
Indomethacin	25.2 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Isoniazid	59.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Ketoconazole	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Lamivudine	160.7 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Lidocaine	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Lonidamine	18.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
lovastatin	4.4 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
lumiracoxib	26.3 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Manganese	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Mefenamic acid	10.1 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Metformin	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Mitomycin	4.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Nicotine	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
nifuroxazide	61.5 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Nimesulide	< 25 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Nitrofurantoin	232.3 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Perhexiline	88.4 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Piroxicam	224.5 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
pravastatin	5 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
propylparaben	63 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Pyrazinamide	107.5 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
resveratrol	7.7 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
riboflavin	264.6 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
rifampicin	124.1 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
ritonavir	35.5 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Salicylic acid	354.4 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Simvastatin	1.6 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
sorafenib	283.4 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Sulindac	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Oligomycin	8 nM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	IC50	3
aurovertin B	1.5 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	IC50	3
Amiodarone	50 μM		bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	p < 0.05	3
Amiodarone	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Amiodarone	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Amiodarone	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	decrease	Positive	p < 0.05	3
Amiodarone	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Chlorpromazine	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Chlorpromazine	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Chlorpromazine	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Diclofenac	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.01	3
Cefixime	216.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Chlorambucil	140.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
gefitinib	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	decrease	Positive	p < 0.05	3
gefitinib	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Ibuprofen	132.1 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
imipramine	18.3 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	increase	Positive	EC20	36
Ketoconazole	2.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
paroxetine	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Simvastatin	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Salicylic acid	120.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Simvastatin	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Sulindac	35.6 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Tolfenamic Acid	238.7 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	increase	Positive	EC20	36
Tamoxifen	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Valproic Acid	44.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Zidovudine	242.0 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	increase	Positive	EC20	36
Simvastatin	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	decrease	Positive	p < 0.001	3
Tamoxifen	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Tamoxifen	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Tamoxifen	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	decrease	Positive	p < 0.001	3
Tamoxifen	26.6 μM		bovine	heart mitochondria	Measurement of complex IV activity	decrease	Positive	IC50	3
Tamoxifen	4 μM		bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	IC50	3
Tamoxifen	1.6 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	IC50	3
Tamoxifen	29 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	IC50	3
Tamoxifen	26 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	IC50	3
Tamoxifen	15 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	IC50	3
Tamoxifen	8.1 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	IC50	3
Tamoxifen	30 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	IC50	3
Tamoxifen	30 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	IC50	3
Amiodarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	10 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	20 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	50 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	1 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	10 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Zidovudine						Interfere	Positive		307
Acyclovir						Interfere	Positive		307
Ganciclovir						Interfere	Positive		307
Zalcitabine						Interfere	Positive		307
tetracyclines						decrease	Positive		307
Ciprofloxacin						decrease	Positive		307
Ciprofloxacin						decrease	Positive		307
2‐Butylbenzofuran	50 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05	4
benzarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	10 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Amiodarone	20 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Clozapine						decrease	Positive		307
Amiodarone	50 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
sertraline			rat	brain mitochondria		decrease	Positive		307
Fluoxetine			rat	brain mitochondria		decrease	Positive		307
sertraline			rat	liver mitochondria		decrease	Positive		307
Fluoxetine			rat	liver mitochondria		decrease	Positive		307
benzbromarone	100 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
sertraline						decrease	Positive		307
Fluoxetine						decrease	Positive		307
benzbromarone	1 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
benzbromarone	10 μmol/L		rat; Sprague–Dawley	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.01	4
Flufenamic Acid	2.9 ± 0.3		rat	isolated rat liver mitochondria	State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	UC50 (nmol/mg mitochondrial protein)	40
Tolfenamic Acid	3.4 ± 0.6		rat	isolated rat liver mitochondria	State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	UC50 (nmol/mg mitochondrial protein)	40
Mefenamic acid	17.9 ± 2.2		rat	isolated rat liver mitochondria	State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	UC50 (nmol/mg mitochondrial protein)	40
Meloxicam	22.8 ± 2.8		rat	isolated rat liver mitochondria	State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	UC50 (nmol/mg mitochondrial protein)	40
Sudoxicam	37.4 ± 3.0		rat	isolated rat liver mitochondria	State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	UC50 (nmol/mg mitochondrial protein)	40
Piroxicam	69.0 ± 7.2		rat	isolated rat liver mitochondria	State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	UC50 (nmol/mg mitochondrial protein)	40
Diflunisal	6.7 ± 1.3		rat	isolated rat liver mitochondria	State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	UC50 (nmol/mg mitochondrial protein)	40
Diclofenac	56.3 ± 4.9		rat	isolated rat liver mitochondria	State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	UC50 (nmol/mg mitochondrial protein)	40
Sulindac	> 100		rat	isolated rat liver mitochondria	State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	UC50 (nmol/mg mitochondrial protein)	40
Sulindac sulfide	25.7 ± 4.5		rat	isolated rat liver mitochondria	State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	UC50 (nmol/mg mitochondrial protein)	40
Nimesulide	2.6 ± 0.2		rat	isolated rat liver mitochondria	State 2 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	UC50 (nmol/mg mitochondrial protein)	40
Sulindac sulfide	39.8 ± 2.9		rat	isolated rat liver mitochondria	State 3 respiration ( 96-well plate format using a phosphorescent oxygen-sensitive probe MitoXpress)	inhibit	Positive	IC50 (nmol/mg mitochondrial protein)	40
atorvastatin				C2C12 myoblasts		affect	Positive		180
Cerivastatin	100uM			C2C12 myoblasts	measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds	decrease	Positive		180
pitavastatin	100uM			C2C12 myoblasts	measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds	decrease	Positive		180
lovastatin	100uM			C2C12 myoblasts	measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds	decrease	Positive		180
Simvastatin	100uM			C2C12 myoblasts	Measured ubiquinol:cytochrome c oxidoreductase activity in broken C2C12 mitochondria after acute statin exposure at a fixed concentration for all compounds. The lactone forms of the indicated statins were included in the assay medium at their cytotoxic EC50 concentration for measurement of their effect on the catalytic capacity.	decrease	Positive		180
Simvastatin	200uM		bovine	heart mitochondria	Reduction of the CIII cytochromes c1 and b was determined spectrophotometrically in bovine heart mitochondria.	affect	Positive	p < 0.01	180
Rotenone	263±43 nM	2 minutes	human	HepG2	Measurement of OCR	decrease	Positive	EC50	7
Antimycin A	4±0.2 nM	2 minutes	human	HepG2	Measurement of OCR	decrease	Positive	EC50	7
Oligomycin	0.92± 0.18 μM	2 minutes	human	HepG2	Measurement of OCR	decrease	Positive	EC50	7
FCCP	54±7 nM	2 minutes	human	HepG2	Measurement of OCR	increase	Positive	EC50	7
2-Deoxy-D-glucose	150 mM	2 minutes	human	HepG2	Measurement of OCR	increase	Positive	EC50	7
Tolcapone	3.7 μM	2 minutes	human	HepG2	Measurement of OCR	increase	Positive	EC50	7
Entacapone	33 μM	2 minutes	human	HepG2	Measurement of OCR	increase	Positive	EC50	7
Nilutamide	66 μM	2 minutes	human	HepG2	Measurement of OCR	decrease	Positive	EC50	7
Flutamide	> 100 μM	2 minutes	human	HepG2	Measurement of OCR	decrease	Positive	EC50	7
Chlorpromazine	> 300 μM	2 minutes	human	HepG2	Measurement of OCR	increase	Positive	EC50	7
Diflunisal	15 μM	2 minutes	human	HepG2	Measurement of OCR	increase	Positive	EC50	7
Benoxaprofen	30 μM	2 minutes	human	HepG2	Measurement of ECAR	decrease	Positive	EC50	7
Troglitazone	> 100 μM	2 minutes	human	HepG2	Measurement of ECAR	decrease	Positive	EC50	7
Troglitazone	10-50 μM		ZDF fa/fa rat & ZDF lean rat	isolated liver mitochondria	OCR and measured using a fluorescent oxygen probe (Presens)	decrease	Positive	significantly different from control (p < 0.05)	225
Pioglitazone	25-50 μM		ZDF fa/fa rat & ZDF lean rat	isolated liver mitochondria	OCR and measured using a fluorescent oxygen probe (Presens)	decrease	Positive	significantly different from control (p < 0.05)	225
Ciglitazone	> 100 μM	2 minutes	human	HepG2	Measurement of ECAR	decrease	Positive	EC50	7
Troglitazone	10 μM	2 minutes	feline	cardiomyocytes	Measurement of OCR	increase	Positive	EC50	7
Ciglitazone	> 100 μM	2 minutes	feline	cardiomyocytes	Measurement of OCR	decrease	Positive	EC50	7
Rosiglitazone	> 100 μM	2 minutes	feline	cardiomyocytes	Measurement of OCR	increase	Positive	EC50	7
ionomycin			rat	liver mitochondria	Oxygen consumption and medium pH were monitored simultaneously with a dual channel Gilson oxygraph equipped with a Clark electrode (Yellow Springs Instruments) and a combination pH electrode (Beckman No. 39030).	increase	Positive		202
Metformin	5 mM	24 hours	human	MCF7	Meassurement of mitochondrial respiration	decrease	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	human	MCF7	Meassurement of coupled respiration	decrease	Positive	p < 0.05	172
Metformin	5 mM	24 hours	human	MCF7	Meassurement of coupled respiration	decrease	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	human	MCF7	Meassurement of non-mitochondrial respiration	increase	Positive	p < 0.05	172
Metformin	5 mM	24 hours	human	MCF7	Meassurement of non-mitochondrial respiration	increase	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	mouse	NMuMG	Meassurement of mitochondrial respiration	decrease	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	mouse	NT2196	Meassurement of mitochondrial respiration	decrease	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	human	MCF10A	Meassurement of mitochondrial respiration	decrease	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	human	MCF7	Meassurement of mitochondrial respiration	decrease	Positive	p < 0.05	172
Tolfenamic Acid	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Metformin	0.5 mM	24 hours	human	MCF7	Meassurement of coupled respiration; Meassurement of uncoupled respiration; cells grown in glucose	increase	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	human	MCF7	Meassurement of coupled respiration; Meassurement of uncoupled respiration; cells grown in galactose	increase	Positive	p < 0.05	172
Troglitazone	3.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Metformin	0.5 mM	24 hours	mouse	NMuMG	Meassurement of coupled respiration; Meassurement of uncoupled respiration	increase	Positive	p < 0.05	172
Metformin	0.5 mM	24 hours	human	MCF10A	Meassurement of coupled respiration; Meassurement of uncoupled respiration	increase	Positive	p < 0.05	172
Valproic Acid	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Zidovudine	> 800 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Rotenone (2µM) was used as 100% baseline for complex I inhibition.	decrease	Positive	EC20	36
Acetaminophen	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Acetylsalicylic acid	149.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Metformin	2mM	30 minutes	mouse; C57BL/6J	isolated skeletal muscle mitochondria	Measurement of Oxygen level; incubated in complex I substrate; added ADP (500 μM)	decrease	Positive	p < 0.05	172
alpidem	29.6 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Metformin	2mM	30 minutes	mouse; C57BL/6J	isolated skeletal muscle mitochondria	Measurement of Oxygen level; incubated in complex I substrate; added oligomycin (2.5 μg oligomycin/mg mitochondrial protein)	decrease	Positive	p < 0.05	172
Metformin	2mM	30 minutes	mouse; C57BL/6J	isolated skeletal muscle mitochondria	Measurement of Oxygen level; incubated in complex I substrate; added FCCP (1.5 μM)	decrease	Positive	p < 0.05	172
Amantadine	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Ambroxol	> 200 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Nimesulide	1 mM		rat; Sprague-Dawley Crl:CD (SD) BR	lung microsomes	measurement of oxygen consumption	increase	Positive	p < 0.05	11
Nitrofurantoin	1 mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used glutamate as substrate	decrease	Positive	p < 0.05; 61% inhibition	13
Amoxicillin	188.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	increase	Positive	EC20	36
Nitrofurantoin	50 μM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used glutamate as substrate	decrease	Positive	p < 0.05; 72% inhibition	13
Nitrofurantoin	5 μM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used glutamate as substrate	decrease	Positive	p < 0.05; 38% inhibition	13
Nitrofurantoin	1 mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used β-hydroxybutyrate as substrate	decrease	Positive	p < 0.05	13
Nitrofurantoin	50 μM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used β-hydroxybutyrate as substrate	decrease	Positive	p < 0.05; 60% inhibition	13
Ampicillin	161.2 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	increase	Positive	EC20	36
Nitrofurantoin	5 μM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used β-hydroxybutyrate as substrate	decrease	Positive	p < 0.05	13
Nitrofurantoin	1 mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used α-ketoghttarate as substrate	decrease	Positive	p < 0.05	13
Nitrofurantoin	50 μM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used α-ketoghttarate as substrate	decrease	Positive	p < 0.05; 70% inhibition	13
Nitrofurantoin	5 μM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake; used α-ketoghttarate as substrate	decrease	Positive	p < 0.05	13
Antipyrine	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
nitrofurazone	1mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05; 64% inhibition	13
nitrofurazone	1mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05; 63% inhibition	13
Arsenic trioxide	0.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Nitrofurantoin	1 mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05	13
Nitrofurantoin	0.005mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05	13
Nitrofurantoin	1 mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05	13
lumiracoxib	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Nitrofurantoin	0.05mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05	13
Nitrofurantoin	1 mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05	13
Nitrofurantoin	0.05mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05	13
nitrofurazone	1mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05	13
bisacodyl	52.5 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
nitrofurazone	1mM		mouse; C57B/6J	liver mitochondria	Measurement of oxygen uptake	decrease	Positive	p < 0.05	13
estradiol acetate	> 200 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Bupivacaine	> 800 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
nitrofurazone	5μM		mouse; C57B/6J	mitoplasts	Measurement of oxygen uptake	decrease	Positive	p < 0.05	13
nitrofurazone	5μM		mouse; C57B/6J	mitoplasts	Measurement of oxygen uptake	decrease	Positive	p < 0.05	13
Caffeine	> 400 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Capsaicin	15.7 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Carbamazepine	170.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	increase	Positive	EC20	36
buformin	25 μM	24 hours	human	HepG2 cells	Measurement of OCR	decrease	Positive	p < 0.001	15
Phenformin	25 μM	24 hours	human	HepG2 cells	Measurement of OCR	decrease	Positive	p < 0.001	15
Nefazodone	50 μM		bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	p < 0.001	3
buformin	100 nmol/mg mitochondrial protein		rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
Nefazodone	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.01	3
Phenformin	100 nmol/mg mitochondrial protein		rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
Metformin	500 nmol/mg mitochondrial protein	40 minutes preincubation	rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
buformin	100 nmol/mg mitochondrial protein	40 minutes preincubation	rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
Nefazodone	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.01	3
Phenformin	100 nmol/mg mitochondrial protein	40 minutes preincubation	rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
Clodronate	227.2 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
buformin	100 nmol/mg mitochondrial protein		rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
Metformin	66 mM		Bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	IC50	15
buformin	11.3 mM		Bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	IC50	15
Phenformin	1.2 mM		Bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	IC50	15
Nefazodone	50 μM		bovine	heart mitochondria	Measurement of complex IV activity	decrease	Positive	p < 0.001	3
Nefazodone	50 μM		bovine	heart mitochondria	Measurement of complex V activity	decrease	Positive	p < 0.001	3
Metformin	500 nmol/mg mitochondrial protein	40 min preincubation	rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
curcumin	> 200 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
Phenformin	100 nmol/mg mitochondrial protein	40 min preincubation	rat; Sprague–Dawley	liver mitochondria	Meassurement of respiration	decrease	Positive		15
paroxetine	50 μM		bovine	heart mitochondria	Measurement of complex I activity	decrease	Positive	p < 0.01	3
Daunorubicin	10.9 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
paroxetine	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
dexamethasone valerate	> 200 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36
paroxetine	50 μM		bovine	heart mitochondria	Measurement of complex II + III activity	decrease	Positive	p < 0.001	3
Perhexiline	200 μM		mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	increase	Positive	p < 0.01	193
Perhexiline	100 μM		mouse; Crl/CD-l(1CR)BR Swiss	liver mitochondria	Measurement of oxygen uptake	increase	Positive	p < 0.01	193
Diclofenac	29.8 µM	60 mins	mouse	liver mitochondria	Oxygen consumption was monitored with 50nM MitoXpress ( an oxygen-sensitive phosphorescent dye) using a spectrofluorimeter (Tecan Infinite 200; λExcitation 380nm; λEmission 650nm). Oligomycin A (1µM) was used as 100% baseline for complex II inhibition.	decrease	Positive	EC20	36